Zanidip tablets contain the active ingredient lercanidipine hydrochloride, which is a type of medicine called a calcium channel blocker. Lercanidipine is also available without a brand name, ie as the generic medicine.
Lercanidipine works by slowing the movement of calcium through the muscle cells that are found in the walls of blood vessels. It does this by blocking 'calcium channels' in these muscle cells. Calcium is needed by muscle cells so that they can contract. Lercanidipine reduces the amount of calcium available to muscle cells and so makes them relax.
Lercanidipine acts specifically on the muscle cells in the walls of arteries, causing them to relax. This allows the arteries in the body to widen.
The relaxing and widening of the small arteries in the body decreases the resistance that the heart has to push against in order to pump the blood around the body. This reduces the pressure within the blood vessels. Lercanidipine can therefore be used to lower high blood pressure.
Lercanidipine can also have a widening effect on the small arteries in the heart, which improves the supply of blood, and therefore the oxygen to the heart. This reduces the effort the heart has to make to pump blood around the body.
This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to make sure that the combination is safe.
Lercanidipine may have an additive effect with other medicines that decrease blood pressure, particularly other medicines used to treat high blood pressure (antihypertensives). If the combination of medicines lowers your blood pressure too much it could make you feel dizzy. If this happens to you, you should sit or lie down until the symptoms pass. If you frequently feel dizzy when taking lercanidipine in combination with other medicines that can lower blood pressure you should let your doctor know, as your doses may need adjusting. Other medicines that can decrease blood pressure include the following:
The following medicines may increase the breakdown of lercanidipine by the liver, which could make it less effective:
These medicines should be avoided whilst taking lercanidipine.
The following medicines may decrease the breakdown of lercanidipine by the liver, which could increase the risk of its side effects:
Cimetidine may increase the blood level of lercanidipine and therefore increases the risk of its side effects. It is important that your blood pressure is closely montiored if you are taking this medicine together with cimetidine.
Lercanidipine may increase the blood level of the immunosuppressant medicine ciclosporin. The use of these medicines together should be avoided.
Lercanidipine tablets are also available without a brand name, ie as the generic medicine.