Generic name: Selegiline hydrochlorideBrand names: Zelapar

Why is Zelapar prescribed?

Zelapar is used to help manage the symptoms of Parkinson's disease when treatment with levodopa/carbidopa alone is not working.

Most important fact about Zelapar

Zelapar should not be taken with tricyclic antidepressants or non-selective MAO inhibitors (such as Nardil or Parnate), or selective MAO-B inhibitors. The interaction between these drugs may cause sweating, mental changes or strange behavior, muscle stiffness, loss of consciousness, or death.

How should you take Zelapar?

Zelapar should be taken in the morning before breakfast and without any liquids.

Do not try to push Zelapar through the back foil of the container; instead, peel the back of the Zelapar wrapper off to remove the medication.

  • Storage instructions...Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, tell your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zelapar.

  • Side effects may include:Back pain, dizziness, headache, nasal infection, nausea, pain, sleeplessness, swelling of the mouth, uncontrolled muscle movements, upset stomach

Why should Zelapar not be prescribed?

Do not take Zelapar if you are allergic to selegiline or any of the drug's other ingredients. Also, do not take Zelapar if you are taking the pain killer meperidine.

Special warnings about Zelapar

While being treated with Zelapar, avoid pregnancy, breastfeeding, and the products listed under "Possible food and drug interactions when taking Zelapar."

Tell your doctor about all prescription, over-the-counter, and herbal medications you are taking before beginning treatment with Zelapar. Also, talk to your doctor about your complete medical history before beginning Parkinson's disease therapy.

Possible food and drug interactions when taking Zelapar

If Zelapar is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Zelapar with the following:

DextromethorphanMeperidineMonoamine oxidase inhibitors (MAOIs)Selective serotonin reuptake inhibitors (SSRIs)Tricyclic antidepressants

Special information if you are pregnant or breastfeeding

The effects of Zelapar during pregnancy and breastfeeding are unknown. Talk with your doctor before taking Zelapar if you are pregnant, plan to become pregnant, or are breastfeeding.

Recommended dosage for Zelapar


The usual dose of Zelapar is 1.25 milligrams (mg) once per day for a total of 6 weeks. After 6 weeks, the dosage of Zelapar may be increased to 2.5 mg per day.


Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

  • Symptoms of Zelapar overdose may include:Agitation, breathing problems, clammy/cool skin, convulsion and coma, dizziness, drowsiness, faintess, fever, hallucinations, headache, irregular heartbeat, irregular pulse, irritability, muscle spasms in the jaw, sweating
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