Chromosome 4

What is Chromosome 4?

Chromosome 4 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 4 spans more than 186 million base pairs (the building material of DNA) and represents between 6 and 6.5 percent of the total DNA in cells.

Chromosone 4 contains approximately 1600 genes and approximately 190 million base pairs, of which ~95% have been determined. Image Credit: NIH

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 4 likely contains between 700 and 1,100 genes.

The following are some of the genes located on chromosome 4:

  • ANK2: ankyrin 2, neuronal
  • CRMP1: Collapsin response mediator protein 1, a member of CRMP family
  • CXCL1: chemokine (C-X-C motif) ligand 1, ''scyb1''
  • CXCL2: chemokine (C-X-C motif) ligand 2, ''scyb2''
  • CXCL3: chemokine (C-X-C motif) ligand 3, ''scyb3''
  • CXCL4: chemokine (C-X-C motif) ligand 4, Platelet factor-4, PF-4, ''scyb4''
  • CXCL5: chemokine (C-X-C motif) ligand 5, ''scyb5''
  • CXCL6: chemokine (C-X-C motif) ligand 6, ''scyb6''
  • CXCL7: chemokine (C-X-C motif) ligand 7, PPBP, ''scyb7''
  • CXCL8: chemokine (C-X-C motif) ligand 8, interleukin 8 (IL-8), ''scyb8''
  • CXCL9: chemokine (C-X-C motif) ligand 9, ''scyb9''
  • CXCL10: chemokine (C-X-C motif) ligand 10, ''scyb10''
  • CXCL11: chemokine (C-X-C motif) ligand 11, ''scyb11''
  • CXCL13: chemokine (C-X-C motif) ligand 13, ''scyb13''
  • EVC: Ellis van Creveld syndrome
  • EVC2: Ellis van Creveld syndrome 2 (limbin)
  • FGFR3: fibroblast growth factor receptor 3 (achondroplasia, thanatophoric dwarfism, bladder cancer)
  • FGFRL1: fibroblast growth factor receptor-like 1
  • Complement Factor I: Complement Factor I
  • HTT (Huntington): huntington protein (Huntington's disease)
  • MMAA: methylmalonic aciduria (cobalamin deficiency) cblA type
  • PHOX2B: codes for a homeodomain transcription factor
  • PKD2: polycystic kidney disease 2 (autosomal dominant)
  • PLK4
  • QDPR: quinoid dihydropteridine reductase
  • SNCA: synuclein, alpha (non A4 component of amyloid precursor)
  • UCHL1: ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
  • WFS1: Wolfram syndrome 1 (wolframin)
  • FGF2: Fibroblast growth factor 2 (basic fibroblast growth factor)
  • KDR: Kinase insert domain receptor (Vascular endothelial growth factor receptor 2)
  • IGJ: linker protein for immunoglobulin alpha and mu polypeptides

This article is licensed under the Creative Commons Attribution-ShareAlike License. It uses material from the Wikipedia article on "Chromosome 4 (human)" All material adapted used from Wikipedia is available under the terms of the Creative Commons Attribution-ShareAlike License. Wikipedia® itself is a registered trademark of the Wikimedia Foundation, Inc.

Chromosome 4 Related Diseases

The following are some of the diseases related to genes located on chromosome 4:

  • achondroplasia
  • bladder cancer
  • Crouzonodermoskeletal syndrome
  • Chronic Lymphocytic Leukemia
  • Ellis-van Creveld syndrome
  • Fibrodysplasia ossificans progessiva FOP
  • Hemophilia C
  • Huntington's disease
  • Hemolytic Uremic Syndrome
  • Hirschprung's disease
  • hypochondroplasia
  • methylmalonic acidemia
  • Muenke syndrome
  • nonsyndromic deafness
  • nonsyndromic deafness
  • Ondine's Curse
  • Parkinsons disease
  • polycystic kidney disease
  • Romano-Ward syndrome
  • SADDAN
  • tetrahydrobiopterin deficiency
  • thanatophoric dysplasia
  • thanatophoric dysplasia
  • thanatophoric dysplasia
  • Wolfram syndrome

This article is licensed under the Creative Commons Attribution-ShareAlike License. It uses material from the Wikipedia article on "Chromosome 4 (human)" All material adapted used from Wikipedia is available under the terms of the Creative Commons Attribution-ShareAlike License. Wikipedia® itself is a registered trademark of the Wikimedia Foundation, Inc.