Aclarubicin

Latest prescription information about Aclarubicin. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Generic Name : Aclarubicin

Pronunciation : Ã¤k lá rü ' bï sïn

Therapeutic Classification : Chemotherapy

ICD Code : Y43.3

Trade Name(s): 
India- Klasinomycin.
International- Aclacinon.

Why it is prescribed (Indications) : 
This medication is an anthracycline agent, prescribed for acute non-lymphocytic leukaemia. It has a selective inhibitory effect on the synthesis of RNA in the cells

When it is not to be taken (Contraindications): 

Contraindicated in patients with severe heart disease, bone marrow depression, and hypersensitivity.

Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Adult: IV- Initial: 175-300 mg/m2, divided over 3-7 consecutive days. Maintenance: 25-100 mg/m2 3-4 weekly.

How it should be taken : 
It comes as a solution for injection to be administered by a healthcare provider into the vein.

Warnings and Precautions : 
* Caution should be exercised in patients with history of liver or kidney impairment, radiation-induced heart attack, and use of radiotherapy, during pregnancy and breastfeeding.
* Monitor complete blood counts, liver function, uric acid level in blood regularly while taking this medication.

Side Effects : 
Severe Effects - Heart damage and bone marrow suppression.
Gastrointestinal - Nausea, vomiting, diarrhea, abnormal liver function and gastrointestinal tract inflammation.
Blood - Decrease in blood cells.
Skin - Hair loss.
Genitourinary - Blood in urine.

Other Precautions : 
* Avoid live vaccination during the treatment period.
* Avoid excess dosage.

Storage Conditions : 
IV Inj: Store at room temperature (20 to 25°C). Protect from sunlight. IV Inj (reconstituted solution): Store below 40°C. Use within 24 hours if kept at room temperature.