How does it work?
Adenuric tablets contain the active ingredient febuxostat, which is a type of medicine called a xanthine oxidase inhibitor. Febuxostat is used to treat gout.
Gout is caused by too much uric acid in the blood that leads to a build-up of uric acid crystals in the joints. It is these crystals that cause the characteristic pain and inflammation of gout.
Uric acid is produced by an enzyme in the body called xanthine oxidase. Febuxostat inhibits the action of this enzyme and as a result lowers uric acid levels. By lowering the levels of uric acid in the blood, flare-ups of gout can be prevented.
Adenuric tablets are used for the long term treatment and prevention of gout, but not for immediate treatment of gout flare-ups. Other medicines are used for the rapid relief of gout symptoms.
What is it used for?
- Reducing high blood uric acid levels (hyperuricaemia) in gout and thus preventing gout attacks.
How do I take it?
- Treatment with febuxostat should not be started during an acute attack of gout, as it could initially worsen the attack. It should not be started until the attack has completely subsided.
- When you first start treatment your doctor should normally prescribe you a suitable anti-inflammatory medicine, or colchicine, for at least the first six months of treatment, as febuxostat may cause an attack of gout in the early stages of treatment. If you do get a new attack of gout after you have started treatment with febuxostat you should keep taking it while the attack is treated with a suitable anti-inflammatory medicine. This is because the febuxostat will still be working to lower uric acid. Over time, your attacks will become less frequent and less painful as long as you continue to take the febuxostat every day.
- Adenuric tablets should be taken once a day, preferably at the same time each day.
- The tablets should be swallowed with a drink and can be taken either with or without food.
- If you forget to take a dose just take your next dose as usual. Don't take a double dose to make up for a missed dose.
- You will need to have blood tests to check your liver function before starting and throughout treatment with this medicine.
- This medicine may cause sleepiness, dizziness and blurred vision and so could affect your ability to drive or operate machinary. You should not drive or operate machinary until you know how this medicine affects you and are sure you can perform these activities safely.
- This medicine may rarely cause serious allergic reactions such as anaphylaxis, or a skin reaction called Stevens-Johnson Syndrome. In the unlikely event that you experience an allergic reaction, this is most likely to happen in the first month of taking this medicine. People at increased risk appear to include those who have previously had an allergic reaction to allopurinol and those with kidney problems. You should stop taking this medicine and tell your doctor straight away if you get any of the following symptoms while taking this medicine, as they could be signs of an allergic reaction: a skin rash (appearing initially as reddish target-like spots or circular patches often with a central blister on the trunk); itching, nodules, blistering, ulceration or peeling affecting the skin, inside of the mouth or genitals; eye irritation; swelling of the face or limbs; fever or difficulty breathing. If you have had an allergic reaction to this medicine you should not take it again.
Use with caution in
- People with reduced kidney function.
- People with reduced liver function.
- People with an overactive or underactive thyroid gland.
- People taking theophylline.
- People with a history of allergic reactions to allopurinol (Zyloric).
Not to be used in
- People taking the medicines mercaptopurine or azathioprine.
- People with heart failure or ischaemic heart disease, eg angina or a history of heart attack.
- There is insufficient information regarding the safety and effectiveness of this medicine in people who have had an organ transplant. It is not recommended for people who have had an organ transplant.
- This medicine is not recommended for people being treated for high uric acid levels as a result of cancer or Lesch-Nyhan syndrome (a rare inherited condition in which there is too much uric acid in the blood).
- There is insufficient information regarding the safety and effectiveness of this medicine in children. Adenuric tablets are not recommended for children or adolescents.
- Adenuric tablets contain lactose and are unsuitable for people with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption
This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
- The safety of this medicineduring pregnancy has not been established. It should not be used during pregnancy. If you do get pregnant or want to plan a pregnancy while using this medicine you should consult your doctor.
- It is not known if febuxostat passes into breastmilk. It should not be used by mothers who are breastfeeding. Seek further medical advice from your doctor.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.
Common (affect between 1 in 10 and 1 in 100 people)
- Alteration in results of liver function tests.
- Gout flares.
- Excessive fluid retention in the body tissues, resulting in swelling (oedema).
Uncommon (affect between 1 in 100 and 1 in 1000 people)
- Difficulty sleeping (insomnia).
- Pins and needles or numb sensations.
- Reduced sense of smell.
- Changes in taste.
- Dry mouth.
- Disturbances of the gut such as vomiting, abdominal pain or bloating, indigestion, heartburn, constipation, flatulence (wind).
- Pain or inflammation in the joints.
- Muscle spasms, weakness, tightness or pain.
- Weakness on one side of the body.
- Skin reactions, such as dermatitis, hive-like rash, itching, skin discolouration.
- Decreased appetite.
- Increased weight.
- Increased levels of fats such as cholesterol or triglycerides in the blood (hyperlipidaemia).
- Kidney stones (nephrolithiasis).
- Kidney failure.
- Increased urine production, blood in the urine.
- High blood pressure.
- Irregular heartbeat (atrial fibrillation) or awareness of your heartbeat (palpitations).
- Chest pain.
- Hot flushes.
- Shortness of breath, cough.
- Decreased sex drive, erectile dysfunction.
- Increased levels of thyroid stimulating hormone.
Rare (affect between 1 in 1000 and 1 in 10,000 people)
- Blurred vision.
- Mouth ulcers.
- Hair loss.
- Excessive sweating.
- Feeling thirsty.
- Weight loss.
- Increased appetite or loss of appetite.
- Sensation of ringing or other noise in the ears (tinnitus).
- Severe allergic reactions, including anaphylaxis and severe skin reactions (see warning section above).
- Decreased numbers of platelets in the blood (thrombocytopenia).
- Inflammation of the pancreas (pancreatitis).
- Jaundice or inflammation of the liver (hepatitis).
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to make sure that the combination is safe.
Febuxostat increases the effects of azathioprine and mercaptopurine. This medicine should not be used in combination with azathioprine or mercaptopurine.
Febuxostat may increase the blood level of theophylline. If you are taking theophylline your doctor should check your theophylline blood level after you start treatment with this medicine.
Other medicines containing the same active ingredient
There are currently no other medicines available in the UK that contain febuxostat as the active ingredient.