Adesan HCT

What Adesan HCT 16/12.5 is used for

Adesan HCT 16/12.5 is used to treat high blood pressure.

Candesartan cilexetil is a type of medicine called an angiotensin II - receptor antagonist. It mainly works by causing relaxation of blood vessels.

Hydrochlorothiazide is a type of medicine called a diuretic. It works by reducing the amount of excess fluid in the body.

Using these two medicines together will lower your blood pressure more than using either one on its own.

Your doctor will have explained why you are being treated with Adesan HCT 16/12.5 and told you what dose to take.

Follow all directions given to you by your doctor carefully.

They may differ from the information contained in this leaflet.

Your doctor may prescribe this medicine for another use. Ask your doctor if you want more information.

There is no evidence that Adesan HCT 16/12.5 is addictive.

Before you take [Medicine name]

When you must not take it

Do not use Adesan HCT 16/12.5 if you have an allergy to:

  • any medicine containing candesartan cilexetil, or hydrochlorothiazide
  • any of the ingredients listed at the end of this leaflet
  • any sulphur drugs (sulphonamides) such as some antibiotics or some medicines to treat diabetes

Some of the symptoms of an allergic reaction may include:

  • shortness of breath
  • wheezing or difficulty breathing
  • swelling of the face, lips, tongue or other parts of the body
  • rash, itching or hives on the skin

Do not use Adesan HCT 16/12.5 if you have:

  • severe kidney or liver disease
  • gout

Do not use Adesan HCT 16/12.5 if you are pregnant or are planning to become pregnant.

It may affect your baby if you take it during pregnancy.

Do not use Adesan HCT 16/12.5 if you are breastfeeding.

Your baby can take in Adesan HCT 16/12.5 from breast milk if you are breastfeeding.

Do not give Adesan HCT 16/12.5 to children.

There is no information about its use in children.

Do not use Adesan HCT 16/12.5 after the use by (expiry) date printed on the pack or if the packaging is torn or shows signs of tampering.

If it has expired or is damaged, return it to your pharmacist for disposal.

If you are not sure whether you should start taking this medicine, talk to your doctor.

Before you start to use it

Tell your doctor if you have allergies to any other medicines, foods, preservatives or dyes.

Tell your doctor if you have any of the following medical conditions:

  • kidney problems
  • liver problems
  • heart problems
  • diabetes
  • recent excessive vomiting or diarrhoea
  • Systemic Lupus Erythematosus (SLE), a disease affecting the skin, joints and kidneys
  • a salt restricted diet
  • a past operation known as sympathectomy

If you have not told you doctor about any of the above, tell him/her before you start taking Adesan HCT 16/12.5.

Taking other medicines

Tell your doctor if you are taking any other medicines, including any that you get without a prescription from a pharmacy, supermarket or health food shop.

Some medicines and Adesan HCT 16/12.5 may interfere with each other. These include:

  • Other blood pressure lowering medicines
  • Any containing potassium, including salt substitutes
  • Digoxin, a medicine used to treat heart failure
  • Non-steroidal anti-inflammatory drugs (NSAIDs), medicines used to relieve pain, swelling and other symptoms of inflammation, including arthritis
  • Colestipol and cholestyramine, medicines used to treat high blood cholesterol levels
  • Lithium, a medicine used to treat mood swings and some types of depression
  • Alcohol
  • Strong pain killer such as codeine, morphine, dextropropoxyphene
  • Barbiturates, used to treat epilepsy, such as phenobarbitone
  • Medicines used to treat diabetes
  • Calcium supplements, or medicines containing calcium
  • Medicines to treat irregular heart beats
  • Corticosteroids such as prednisone, cortisone, dexamethasone

These medicines may be affected by Adesan HCT 16/12.5 or may affect how it works. You may need different amounts of your medicines, or may need to take different medicines.

Your doctor and pharmacist have more information on medicines to be careful with or avoid while taking this medicine.

How to take Adesan HCT 16/12.5

Follow all directions given to you by your doctor or pharmacist carefully.

This may differ from the information contained in this leaflet.

If you do not understand the instructions on the label, ask your doctor or pharmacist for help.

How to take it

The usual dose is one tablet once daily, taken whole with a glass of water.

Take Adesan HCT 16/12.5 once a day, at about the same time each day.

Keeping a regular time for taking Adesan HCT 16/12.5 will help to remind you to take it.

It does not matter whether you take Adesan HCT 16/12.5 with food or on an empty stomach.

How long to take it

Adesan HCT 16/12.5 helps control your condition, but does not cure it. Therefore, you must take Adesan HCT 16/12.5 every day. Continue taking the tablets as long as your doctor tells you to.

If you forget to take it

If you forget to take a dose, take it as soon as you remember, as long as it is at least 12 hours before your next dose is due.

Then go back to taking it as you would normally.

If it is less than 12 hours to your next dose, skip the dose you missed and take your next does when you are meant to.

Do not double the dose.

If you have trouble remembering when to take your medicine, ask your pharmacist for some hints.

If you take too much (Overdose)

Immediately telephone your doctor or the Australian Poisons Information Centre (telephone 13 11 26), or go to Accident and Emergency at your nearest hospital immediately if you think you or anyone else may have taken too much Adesan HCT 16/12.5 even if there are no signs of discomfort or poisoning.

If you take too many Adesan HCT 16/12.5 you will probably get a headache, feel sick (nausea), dizzy, thirsty and very tired.

While you are taking Adesan HCT 16/12.5

Things you must do

Take Adesan HCT 16/12.5 exactly as your doctor has told you to.

Your blood pressure will not be well controlled if you do not.

Tell your doctors if you have excessive vomiting or diarrhoea while taking Adesan HCT 16/12.5.

You may lose too much water and your blood pressure may become too low.

Tell your doctor, dentist and pharmacist who are treating you that you are taking Adesan HCT 16/12.5.

Tell your doctor immediately if you become pregnant while you are taking Adesan HCT 16/12.5.

It may affect your baby if you take it during pregnancy.

Things you must not do

Do not use it to treat any other complaints unless your doctor says to.

Do not give this medicine to anyone else, even if their symptoms seem similar to yours.

Things to be careful of

Move slowly when getting out of bed or standing up if you feel faint, dizzy or light-headed.

Be careful driving or operating machinery until you know how Adesan HCT 16/12.5 affects you.

You may feel dizzy when you start taking Adesan HCT 16/12.5 due to the drop in your blood pressure.

Drink plenty of water while you are using Adesan HCT 16/12.5, especially if you sweat a lot.

Please talk to your doctor or pharmacist about these possibilities if you think they may bother you.

Lifestyle measures that help reduce heart disease risk

By following these simple measures, you can further reduce the risk from heart disease.

  • Quit smoking and avoid second-hand smoke.
  • Limit alcohol intake.
  • Enjoy healthy eating by:
eating plenty of vegetables and fruit;
reducing your saturated fat intake (eat less fatty meats, full fat dairy products, butter, coconut and palm oils, most take-away foods, commercially-baked products).
  • Be active. Progress, over time, to at least 30 minutes of moderate-intensity physical activity on 5 or more days each week. Can be accumulated in shorter bouts of 10 minutes duration. If you have been prescribed anti-angina medicine, carry it with you when being physically active.
  • Maintain a healthy weight.
  • Discuss your lifestyle and lifestyle plans with your doctor.
  • For more information and tools to improve your heart health, call Heartline, the Heart Foundation's national telephone information service, on 1300 36 27 87 (local call cost).

Know warning signs of heart attack and what to do:

  • Tightness, fullness, pressure, squeezing, heaviness or pain in your chest, neck, jaw, throat, shoulders, arms or back.
  • You may also have difficulty breathing, or have a cold sweat or feel dizzy or light headed or feel like vomiting (or actually vomit).

If you have heart attack warning signs that are severe, get worse or last for 10 minutes even if they are mild, call triple zero (000). Every minute counts.

Side effects

Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking Adesan HCT 16/12.5.

Adesan HCT 16/12.5 helps most people with high blood pressure, but it may have unwanted side effects in a few people.

All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.

Ask your doctor or pharmacist to answer any questions you may have.

Tell your doctor if you notice any of the following and they worry you:

  • headache or dizziness
  • flu-like symptoms or infections
  • chest, throat or sinus infections
  • feeling sick (nausea)
  • back pain
  • urinary tract infection
  • rapid heartbeats
  • feeling tired
  • stomach ache

These are all mild side effects of Adesan HCT 16/12.5.

The following side effects have been reported very rarely by patients taking candesartan cilexetil: palpitations, agitation, anxiety, depression, trouble sleeping (insomnia), drowsiness (somnolence), nervousness, nightmare and sleep disorder. It is not known if these side effects are caused by candesartan cilexetil.

Tell your doctor as soon as possible if you notice any of the following:

  • aching muscles, tenderness or weakness in the muscle

The above list includes serious side effects that may require medical attention. Serious side effects are rare.

If any of the following happen, stop taking Adesan HCT 16/12.5 and tell your doctor immediately or go to casualty at your nearest hospital.

  • swelling of the face, lips, tongue or throat
  • harsh sounds when breathing
  • rash, itching or hives
  • easy bruising or bleeding more easily than normal
  • feel extremely tired
  • yellowing of the skin and eyes
  • signs of frequent infections such as fever, severe chills, sore throat or mouth ulcers
  • worsening of the kidney function (including passing little or no urine, drowsiness, nausea, vomiting, breathlessness, loss of appetite and weakness (especially in patients with existing kidney problems or heart failure).
  • changes in your potassium, sodium and red or white blood cell levels may occur. Such changes are usually detected by a blood test.symptoms that may indicate high potassium levels in the blood include nausea, diarrhoea, muscle weakness and changes in heart rhythm.

These are very serious side effects. If you have them, you may have had a serious reaction to Adesan HCT 16/12.5. You may need urgent medical attention or hospitalisation.

These side effects are very rare.

Tell your doctor if you notice anything else that is making you feel unwell.

Some people may get other side effects while taking Adesan HCT 16/12.5.

After taking Adesan HCT 16/12.5


Keep your medicine in the blister pack until it is time to take them.

If you take Adesan HCT 16/12.5 out of the blister pack it will not keep well.

Keep it in a cool, dry place and protect from light, where the temperature stays below 25°C.

Do not store it or any other medicine in the bathroom or near a sink. Do not leave it on window sills or in the car on hot days.

Heat and dampness can destroy some medicines.

Keep it where young children cannot reach it.

A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.


Ask your pharmacist what to do with any medicine you have left over if your doctor tells you to stop taking them, or you find that the expiry date has passed.

Product description

What it looks like

Adesan HCT 16/12.5 tablets are peach colour, mottled, round, biconvex tablet debossed with "M" on one side and "CH2" on the other.

Adesan HCT 16/12.5 is available in blister packs of 30's.


Each Adesan HCT 16/12.5 tablet contains active ingredient candesartan cilexetil 16 mg and hydrochlorothiazide 12.5 mg.

The tablets also contain the following inactive ingredients:

  • lactose
  • carmellose calcium
  • glycerol monostearate
  • hydroxypropylcellulose
  • iron oxide yellow CI77492
  • iron oxide red CI77491
  • starch - maize
  • magnesium stearate