Generic Name: Fluorouracil (FLURE-oh-UE-ra-sil)Brand Name: Adrucil

Adrucil should only be given by a health care provider in a medical setting. You will need to be in a health care facility the first time you take it due to the possibility of a severe reaction.

Adrucil is used for:

Treating symptoms of colon, rectum, breast, stomach, and pancreas cancer.

Adrucil is an antimetabolite. It works by interfering with the production of proteins necessary for cell growth and reproduction.

Do NOT use Adrucil if:

  • you are allergic to any ingredient in Adrucil
  • you have a serious infection or are malnourished
  • you are taking sorivudine

Contact your doctor or health care provider right away if any of these apply to you.

Before using Adrucil :

Some medical conditions may interact with Adrucil . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have impaired liver or kidney function

Some MEDICINES MAY INTERACT with Adrucil . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Amphotericin B, cimetidine, folic acid, interferon alfa, leucovorin, metronidazole, sorivudine, tamoxifen, thiazide-type diuretics (eg, hydrochlorothiazide), or vinca alkaloids (eg, vincristine) because they may increase Adrucil 's side effects
  • Anticoagulants (eg, warfarin) or hydantoins (eg, phenytoin) because they may increase Adrucil 's side effects
  • Carbamazepine or quinolones (eg, ciprofloxacin) because their effectiveness may be decreased by Adrucil

This may not be a complete list of all interactions that may occur. Ask your health care provider if Adrucil may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Adrucil :

Use Adrucil as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Adrucil is usually given as an injection at your doctor's office, hospital, or clinic.
  • Do not use Adrucil if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If you take methotrexate, ask your doctor or pharmacist how to take it with Adrucil .
  • If you miss a dose of Adrucil , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Adrucil .

Important safety information:

  • Adrucil may lower the ability of your body to fight infection. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • If nausea, vomiting, or loss of appetite occur, ask your doctor, nurse, or pharmacist for ways to lessen these effects.
  • talk with your doctor before you receive any vaccine while you are using Adrucil .
  • Adrucil may reduce the number of clot-forming cells (platelets) in your blood. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Adrucil may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Adrucil . Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Lab tests, including complete blood cell count, may be performed while you use Adrucil . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • PREGNANCY and BREAST-FEEDING: Adrucil has been shown to cause harm to the human fetus. If you plan on becoming pregnant, contact your doctor. You will need to discuss the benefits and risks of using Adrucil while you are pregnant. It is not known if Adrucil is found in breast milk. Do not breast-feed while taking Adrucil .

Possible side effects of Adrucil :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Changes in eyesight; dry skin; fatigue or weakness; hair loss; headache; itchy rash; loss of appetite; nail changes; nausea.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bleeding; blood in the urine; bloody stools; chest pain; chills; fever; frequent diarrhea; inflammation of the mouth or throat; joint pain; lower back or abdominal pain; pain, redness, or swelling at the injection site; painful urination; severe vomiting; sore throat; sores on the mouth or lips; unusual bruising or bleeding; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include diarrhea; intestinal bleeding; nausea; vomiting.

Proper storage of Adrucil :

Adrucil is usually handled and stored by a health care provider. If you are using Adrucil at home, store Adrucil as directed by your pharmacist or health care provider. Keep Adrucil out of the reach of children and away from pets.

General information:

  • If you have any questions about Adrucil , please talk with your doctor, pharmacist, or other health care provider.
  • Adrucil is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Adrucil . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Adrucil Advanced Consumer (Micromedex) - Includes Dosage Information
  • Adrucil injection Concise Consumer Information (Cerner Multum)
  • Adrucil Prescribing Information (FDA)
  • Fluorouracil Detailed Consumer Information (PDR)
  • Fluorouracil Professional Patient Advice (Wolters Kluwer)