Alvedon suppositories (Paracetamol)

How does it work?

Alvedon suppositories contain the active ingredient paracetamol, which is a simple painkilling medicine used to relieve mild to moderate pain and fever. (NB. Paracetamol is also available without a brand name, ie as the generic medicine, in many forms, including suppositories.)

Despite its widespread use for over 100 years, we still don't fully understand how paracetamol works to relieve pain and reduce fever. However, it is now thought that it works by reducing the production of prostaglandins in the brain and spinal cord.

Prostaglandins are produced by the body in response to injury and certain diseases. One of their actions is to sensitise nerve endings, so that when the injury is stimulated it causes pain (presumably to prevent us from causing further harm to the area). As paracetamol reduces the production of these nerve sensitising prostaglandins it is thought it may increase our pain threshold, so that although the injury remains, we can feel it less.

It is thought paracetamol reduces fever by affecting an area of the brain that regulates our body temperature (the hypothalamic heat-regulating center).

Paracetamol is about as effective as aspirin at relieving mild to moderate pain and reducing fever, but unlike aspirin it has no anti-inflammatory effect.

Paracetamol can be used to relieve mild to moderate pain associated with conditions such as headaches, migraine, toothache, teething, colds and flu. It is also useful for reducing fever and discomfort associated with colds and flu and following vaccinations.

Paracetamol suppositories may be especially useful for people who can't take paracetamol by mouth, for example because they feel or are being sick, or have just had an operation.

The suppositories melt in the rectum and the paracetamol is then absorbed into the bloodstream through the rich supply of blood vessels found in this area.

Alvedon suppositories contain children's doses of paracetamol.

What is it used for?

  • Mild to moderate pain and fever in children.


  • Alvedon suppositories are for rectal use only and should not be taken by mouth.
  • Different strengths of Alvedon suppositories are suitable for children of different ages. Make sure you use the correct strength for your child. Do not exceed the dose stated in the information leaflet supplied with the medicine.
  • This medicine must not be given with any other paracetamol containing products.
  • An overdose of paracetamol is dangerous and capable of causing serious damage to the liver and kidneys. You should never exceed the dose stated in the information leaflet supplied with the medicine. Immediate medical advice should be sought in the event of an overdose with this medicine, even if the child seems well, because of the risk of delayed, serious liver damage.
  • If your child's symptoms persist consult your doctor.

Use with caution in

  • Decreased kidney function.
  • Decreased liver function.

Not to be used in

  • Known sensitivity or allergy to any ingredient.

This medicine should not be used if your child is allergic to one or any of its ingredients. Please inform your doctor or pharmacist if your child has previously experienced such an allergy.If you feel your child has experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Label warnings

  • Do not use this medication with any other products containing paracetamol.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all children using this medicine will experience that or any side effect.

  • Redness in or around the back passage (rectum).
  • Skin rash or itch.

The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

You should not give your child other medicines that contain paracetamol in combination with this medicine, as this can easily result in exceeding the maximum recommended daily dose of paracetamol. Many cold and flu remedies and over-the-counter painkillers contain paracetamol, so be sure to check the ingredients of any other medicines before giving them in combination with this one, or ask your pharmacist for advice.

Long-term or regular use of paracetamol may increase the anti-blood-clotting effect of warfarin and other anticoagulant medicines, leading to an increased risk of bleeding. Regular monitoring of blood clotting times should be performed if paracetamol is used regularly with these medicines. This effect does not occur with occasional pain-killing doses.

Other medicines containing the same active ingredient

Anadin paracetamol Calpol Disprol
Fennings children's cooling powders Hedex Medinol
Panadol Perfalgan infusion

Paracetamol tablets, capsules, caplets, soluble tablets, suspension and suppositories are also widely available without brand names, ie as the generic medicine.

The quantity and strength of paracetamol supplied in the container or packet will determine whether it can be bought only from pharmacies, or from other retail outlets such as supermarkets and garages.

NB. Paracetamol is known as acetaminophen in the USA and some other countries.