The name of your medicine is APO-Irbesartan HCTZ. It contains the active ingredient irbesartan and hydrochlorothiazide (HCTZ).
It is used to treat high blood pressure, which doctors call hypertension.
Everyone has blood pressure. This pressure helps get your blood all around your body. Your blood pressure may be different at different times of the day, depending on how busy or worried you are. You have hypertension (high blood pressure) which means your blood pressure stays high, even when you are calm and relaxed.
There are usually no symptoms of high blood pressure. The only way of knowing that you have hypertension is to have your blood pressure checked on a regularly basis.
Ask your doctor if you have any questions about why this medicine has been prescribed for you. Your doctor may have prescribed this medicine for another reason.
This medicine is available only with a doctor's prescription.
APO-Irbesartan HCTZ contains irbesartan and hydrochlorothiazide. Both medicines reduce blood pressure in different ways.
Irbesartan belongs to a group of medicines known as angiotensin-II receptor Antagonists. Angiotensin II is a substance produced in the body which causes blood vessels to tighten. Irbesartan blocks angiotensin-II and therefore relaxes your blood vessels. This helps to lower your blood pressure.
Hydrochlorothiazide belongs to the class of medicines known as diuretics. Diuretics cause an increase in the volume of urine. They also help with lowering blood pressure particularly when combined with other blood pressure reducing medicines.
There is no evidence that this medicine is addictive.
This medicine should not be given to a child.
Do not take this medicine if:
Symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue, throat or other parts of the body, itching or hives on the skin.
If you think you are having an allergic reaction, contact your doctor immediately or go to the Accident and Emergency department at the nearest hospital.
Do not use this medicine to treat any other complaints unless your doctor tells you to.
Do not give this medicine to anyone else.
Before you start taking this medicine, tell your doctor if:
1. You have or have had any medical conditions, especially the following:
2. You are currently pregnant or breastfeeding or you plan to become pregnant or breastfeed.
3. You are planning to have surgery.
4. You are currently receiving or are planning to receive dental treatment.
5. You have had an allergic reaction to:
Before you start taking this medicine, tell your doctor if you are taking or are planning to take any other medicines, This includes vitamins and supplements that are available from your pharmacy, supermarket or health food shop.
Some medicines may interact with Irbesartan HCTZ. These include:
If you are taking any of these you may need a different dose or you may need to take different medicines.
Other medicines not listed above may also interact with irbesartan HCTZ.
Follow carefully all directions given to you by your doctor or pharmacist. Their instructions may be different to the information in this leaflet.
Your doctor or pharmacist will tell you how much of this medicine you should take. This will depend on your condition and whether you are taking any other medicines.
Usually patients start with one 150/12.5 mg tablet once a day, however some patients may need a lower starting dose. Your doctor will tell you if this is necessary. The full blood pressure lowering effect of Irbesartan HCTZ should be reached about 6-8 weeks after starting treatment.
Depending on how your blood pressure responds, your daily dose of Irbesartan HCTZ may need to be increased. Most patients take either 150/12.5mg or 300mg/12.5 each day. However the daily dose should not exceed 300/25 mg.
Do not stop taking your medicine or change your dosage without first checking with your doctor.
The tablets should be swallowed whole with a drink of water.
Take this medicine at the same time each day. Taking it at the same time each day will have the best effect and will also help you remember when to take it.
To help you remember to take your tablets each day, APO-Irbesartan HCTZ tablets are supplied in a Calendar pack with the foil backing marked with the days of the week. This may help you to remember to take your tablets. All of the tablets in the pack are the same.
When you start a new strip of tablets, take the tablet marked "START". On the next day, take the tablet marked with the relevant day of the week.
Continue taking your tablets each day until all of the tablets are taken. Commence the next strip at "START" and continue as before.
It does not matter if you take APO-Irbesartan HCTZ before or after food.
Continue taking your medicine for as long as your doctor tells you.
Make sure you have enough to last over weekends and holidays.
If it is almost time to take your next dose, skip the missed dose and take your next dose at the usual time. Otherwise take it as soon as you remember and then go back to taking your medicine as you would normally.
Do not take a double dose to make up for missed doses.
This may increase the chance of unwanted side effects.
If you have trouble remembering to take your medicine, ask your pharmacist for some hints to help you remember.
If you think that you or anyone else may have taken too much of this medicine, immediately telephone your doctor or the Poisons Information Centre (Tel: 13 11 26 in Australia) for advice. Alternatively go to the Accident and Emergency Department at your nearest hospital.
Do this even if there are no signs of discomfort or poisoning. You may need urgent medical attention.
Tell your doctor that you are taking this medicine if:
Get up slowly when getting out of bed or standing up especially during the first few doses or if your dose is increased. You may feel light-headed or dizzy while taking this medicine. This may become worse if you stand up quickly as your blood pressure may fall. Standing up slowly, especially when you get up from bed or chairs, will help your body get used to the change in position and blood pressure. If this occurs, talk to your doctor.
Make sure you drink enough water during exercise and hot weather, especially if you sweat a lot. If you do not drink enough water, you may faint or feel lightheaded or sick. This is because your body does not have enough fluid and your blood pressure is low. If you continue to feel unwell, tell your doctor.
If you have excessive vomiting and/or diarrhoea while taking this medicine, tell your doctor. This can also mean that you are losing too much water and your blood pressure may become too low.
Your doctor may occasionally do tests to make sure the medicine is working and to prevent side effects. Go to your doctor regularly for a check-up.
Tell any other doctors, dentists and pharmacists who are treating you that you take this medicine.
Be careful when driving or operating machinery until you know how this medicine affects you.
As with many other medicines used to treat high blood pressure, Irbesartan HCTZ may cause dizziness or light-headedness in some people.
If you drink alcohol, dizziness or light-headedness may be worse.
The hydrochlorothiazide contained in this medicine could produce a positive analytical result in an antidoping test.
Tell your doctor or pharmacist as soon as possible if you do not feel well while you are taking irbesartan HCTZ or if you have any questions or concerns.
Do not be alarmed by the following lists of side effects. You may not experience any of them. All medicines can have side effects. Sometimes they are serious but most of the time they are not.
Tell your doctor or pharmacist if you notice any of the following and they worry you.
This list includes the more common side effects. Mostly, these are mild:
Tell your doctor as soon as possible if you notice any of the following.
These may be serious side effects. You may need medical attention. Most of these side effects are rare.
Other side effects not listed above may occur in some patients.
If you think you are having an allergic reaction to Irbesartan HCTZ, tell your doctor immediately or go to the Accident and Emergency department at your nearest hospital.
Symptoms of an allergic reaction may include some or all of the following:
Keep your medicine in its original packaging until it is time to take it.
If you take your medicine out of its original packaging it may not keep well.
Keep your medicine in a cool dry place where the temperature will stay below 25°C.
Do not store your medicine, or any other medicine, in the bathroom or near a sink. Do not leave it on a window sill or in the car. Heat and dampness can destroy some medicines.
Keep this medicine where children cannot reach it.
A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.
If your doctor or pharmacist tells you to stop taking this medicine or they have passed their expiry date, your pharmacist can dispose of the remaining medicine safely.
APO-Irbesartan HCTZ 150/12.5 mg is a peach coloured, oval shaped biconvex film-coated tablet, engraved "APO" on one side and "150/12.5" on the other side.
APO-Irbesartan HCTZ 300/12.5 mg is a peach coloured, oval shaped biconvex film-coated tablet, engraved "APO" on one side and "300/12.5" on the other side.
APO-Irbesartan HCTZ 300/25 mg is a pink coloured, oval shaped biconvex film-coated tablet, engraved "APO" on one side and "300/25" on the other
Each APO-Irbesartan HCTZ 150/12.5 mg tablet contains 150 mg of irbesartan and 12.5 mg of hydrochlorothiazide as the active ingredients.
Each APO-Irbesartan HCTZ 300/12.5 mg tablet contains 300 mg of irbesartan and 12.5 mg of hydrochlorothiazide as the active ingredients.
Each APO-Irbesartan HCTZ 300/25 mg tablet contains 300 mg of irbesartan and 25 mg of hydrochlorothiazide as the active ingredients.
It also contains the following inactive ingredients:
This medicine is gluten-free, lactose-free, sucrose-free, tartrazine-free and free of other azo dyes.
APO-Irbesartan HCTZ is available in blister packs of 3, 5, 7, 14, 28, 30, 56, 98 tablets and bottles of 30, 90, 100 and 500 tablets*.
*Not all strengths, pack types and/or sizes may be available.
APO-Irbesartan HCTZ 150/12.5 mg tablets (blister pack): AUST R 175211
APO-Irbesartan HCTZ 300/12.5 mg tablets (blister pack): AUST R 175200
APO-Irbesartan HCTZ 300/25 mg tablets (blister pack): AUST R 175202
APO-Irbesartan HCTZ 150/12.5 mg tablets (bottle pack): AUST R 175206
APO-Irbesartan HCTZ 300/12.5 mg tablets (bottle pack): AUST R 175214
APO-Irbesartan HCTZ 300/25 mg tablets (bottle pack): AUST R 175210