Apomorphine (a-poe-MOR-feen)Brand Name:
Apomorphine is used for:
Treating loss of control of body movements such as muscle stiffness, slow movements, or trouble moving associated with advanced Parkinson disease.
Apomorphine is a dopamine agonist. It works by stimulating dopamine receptors, which helps improve motor function.
Do NOT use Apomorphine if:
- you are allergic to any ingredient in Apomorphine (especially sulfites)
- you have decreased consciousness, seizures, or very low blood pressure
- you are taking a 5-HT3 antagonist antiemetic (eg, ondansetron)
Contact your doctor or health care provider right away if any of these apply to you.
Before using Apomorphine :
Some medical conditions may interact with Apomorphine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines (especially sulfa medicines), foods, or other substances
- if you have a history of low blood pressure, fainting, irregular or slow heartbeat, low blood magnesium or potassium levels, asthma, liver problems, kidney problems, heart problems, mental or mood problems, or stroke or other brain problems
- if you regularly drink alcohol
Some MEDICINES MAY INTERACT with Apomorphine . Tell your health care provider if you are taking any other medicines, especially any of the following:
- Medicine for high blood pressure, irregular heartbeat or other heart problems; nitroglycerin; or vasodilators (eg, isosorbide) because they may increase the risk of Apomorphine 's side effects
- 5-HT3 antagonist antiemetics (eg, ondansetron) because the risk of severe low blood pressure and fainting may be increased
- Butyrophenones (eg, haloperidol), metoclopramide, or phenothiazines (eg, chlorpromazine) because they may decrease Apomorphine 's effectiveness
This may not be a complete list of all interactions that may occur. Ask your health care provider if Apomorphine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Apomorphine :
Use Apomorphine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Apomorphine . Talk to your pharmacist if you have questions about this information.
- Apomorphine is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using Apomorphine at home, a health care provider will teach you how to use it. Be sure you understand how to use Apomorphine . Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Apomorphine is for subcutaneous injection only. Do not inject Apomorphine into a vein.
- Make sure you understand how to properly measure each dose of Apomorphine before injecting it. Ask your pharmacist for help if you are unsure of how to measure your dose.
- Rotate sites where the medicine is injected. Do not always use the same site.
- Do not inject medicine into a site that is sore, red, infected, or damaged.
- Do not use Apomorphine if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Your doctor may prescribe another medicine called an antiemetic before you start taking Apomorphine to lessen the nausea and vomiting that can occur when taking Apomorphine . You may need to continue taking the antiemetic for the first 2 months of therapy.
- Keep this product, as well as syringes and needles, out of the reach of children and pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If you miss a dose of Apomorphine , use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use Apomorphine .
Important safety information:
- Apomorphine may cause drowsiness, dizziness, or cause you to fall asleep without warning. These effects may be worse if you take it with alcohol or certain medicines. Use Apomorphine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Apomorphine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Some of these products contain sulfites. Sulfites may cause an allergic reaction in some patients (eg, asthma patients). If you have ever had an allergic reaction to sulfites, ask your pharmacist if your product has sulfites in it.
- Apomorphine may rarely cause a prolonged, painful erection. This could happen even when you are not having sex. If this is not treated right away, it could lead to permanent sexual problems such as impotence. Contact your doctor right away if this happens.
- Use Apomorphine with caution in the ELDERLY; they may be more sensitive to its effects, especially confusion and hallucinations.
- Apomorphine should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Apomorphine while you are pregnant. It is not known if Apomorphine is found in breast milk. Do not breast-feed while taking Apomorphine .
Some people who use Apomorphine for a long time may develop a need to continue taking it. People who take high doses are also at risk. This is known as DEPENDENCE or addiction.
Possible side effects of Apomorphine :
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Dizziness; drowsiness; headache; pain, swelling, or redness at the injection site; runny nose; yawning.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); agitation; chest pain; confusion; difficulty moving; fainting; falling asleep without warning; falling down; fast or irregular heartbeat; hallucinations; mental or mood changes such as depression; painful or prolonged erection; severe dizziness, nausea, or vomiting; shortness of breath; sudden uncontrollable movements; sweating; swelling of the arms, hands, legs, or feet; unusual changes in sexual behavior, desire, or ability; vision changes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include agitation; chest pain; confusion; difficulty moving; grogginess; lightheadedness especially upon standing; loss of consciousness; severe nausea or vomiting; slow heartbeat.Proper storage of Apomorphine :
Store Apomorphine at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Apomorphine out of the reach of children and away from pets.
- If you have any questions about Apomorphine , please talk with your doctor, pharmacist, or other health care provider.
- Apomorphine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
This information is a summary only. It does not contain all information about Apomorphine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
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