Trade Names:Iopidine- Ophthalmic Solution 0.5% (as base)- Solution 1% (as base)Iopidine 0.5% (Canada)Iopidine 1% (Canada)
Relatively selective ophthalmic alpha-adrenergic agonist, used to reduce IOP and has minimal effect on cardiovascular parameters.
3 to 5 h.
Short-term adjunctive therapy in patients on maximally tolerated medical therapy who require additional IOP reduction.1% solution
Control or prevent postsurgical elevations in IOP that occur in patients after argon laser trabeculoplasty, Nd: YAG posterior capsulotomy, or iridotomy.
Hypersensitivity to any component of this medication or to clonidine; concurrent MAOI therapy.
Ophthalmic Instill 1 to 2 drops in affected eye(s) 3 times daily. Apraclondine 0.5% will be used with other ocular glaucoma therapies, use approximately 5 min interval between instillation of each medication to prevent washout of previous dose.1% solution
Ophthalmic Instill 1 drop in scheduled operative eye 1 h before initiating anterior segment laser surgery. Instill second drop into same eye immediately upon completion of surgery.
Store in refrigerator or at controlled room temperature (34° to 77°F). Protect from freezing and light. Keep dropper bottle tightly closed. Store 0.1 mL plastic ophthalmic dispensers in original pouch and foil overwrap until time of use.
Drugs that may interact include CV agents and MAOIs (see contraindications). May potentiate effects on pulse and BP.
None well documented.
Asthenia; decreased libido; depression; dizziness; dream disturbance; fatigue; headache; insomnia; irritability; nervousness; somnolence.
Arrhythmia; bradycardia; irregular heart rate; palpitations; orthostatic episode; peripheral edema; vasovagal attack.
Abnormal vision; blanching; blurred or dimmed vision; burning; conjunctival microhemorrhage; conjunctivitis; discharge; discomfort; dry eye; dry nose; edema; foreign body sensation; hyperemia; hypotonia; itching; lid edema; lid margin crusting; mydriasis; nasal burning or dryness; nasal decongestion; pharyngitis; pruritus; photophobia; tearing; upper lid elevation.
Abdominal pain or stomach discomfort; constipation; diarrhea; dry mouth; nausea; taste perversion; vomiting.
Asthma; dyspnea; sinusitis.
Abnormal coordination; body heat sensation; chest pain; clammy/sweaty palms; contact dermatitis; extremity pain or numbness; shortness of breath.
Assess patient for allergic-like ocular reaction (eg, hyperemia, pruritus, discomfort, tearing, foreign body sensation, edema of lids and conjunctiva). Inform health care provider if noted or suspected. Be prepared to discontinue apraclonidine.Depression
Monitor patient with depression or history of depression during treatment with apraclonidine. Immediately inform health care provider if depressive symptoms noted or if preexisting depression appears to worsen.IOP
Ensure IOPs are measured and documented in the patient's record before starting therapy and periodically thereafter. Immediately inform health care provider of abnormal readings, including exaggerated reductions in IOP.Visual fields
Ensure visual fields are monitored periodically in patient using apraclonidine to delay argon laser surgery.
Category C .
Undetermined. Consider discontinuing breast-feeding for the day when apraclonidine is used.
Safety and efficacy not established.
Use with caution in patients with severe CV, hypertension, recent MI, cerebral vascular disease, coronary insufficiency, chronic renal failure, Reynaud disease, or thromboangiitis obliterans.
Monitor patients for exaggerated reduction.
May occur, use with caution in patients with a history of such attacks.
Bradycardia, drowsiness, hypothermia.
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