• Procyclidine is used to relieve the symptoms of Parkinson's disease.
  • As your condition improves and your body movements become easier, be careful not to overdo physical activities.
  • The most common side-effects are dry mouth, constipation, blurred vision, and difficulty passing urine.
  • Procyclidine may affect your ability to drive and use machines. Do not drive if you are not fully alert or able to see clearly.

About procyclidine

Type of medicine Antimuscarinic
Used for Parkinson's disease and other similar conditions caused by some treatments
Also called Arpicolin®
Available as Tablets, oral liquid, and injection

Procyclidine is used to relieve the symptoms of Parkinson's disease.

The cause of Parkinson's disease is unknown, but the condition results in a reduction in the amount of a chemical messenger in the brain known as dopamine. This lack of dopamine causes the symptoms of parkinsonism such as loss of muscle control and stiffness. These symptoms are also sometimes experienced by patients who do not have Parkinson's disease, as a side effect of a medicine they are taking.

Procyclidine works by indirectly increasing the effects of dopamine, which relieves the symptoms in both cases.

Before taking procyclidine

Before taking procyclidine make sure your doctor or pharmacist knows:

  • If you are pregnant, trying for a baby or breast-feeding.
  • If you have liver or kidney problems.
  • If you have heart or blood vessel problems.
  • If you have prostate problems, or have been experiencing difficulty passing urine.
  • If you have been constipated for more than one week.
  • If you have glaucoma (increased pressure in your eye).
  • If you have high blood pressure.
  • If you have myasthenia gravis (a condition causing tired and weak muscles).
  • If you have ever had psychosis (a mental health problem).
  • If you are taking other medicines, including those available to buy without a prescription, herbal or complementary medicines.
  • If you have ever had an allergic reaction to this or to any other medicine.

How to take procyclidine

  • Before starting this treatment, read the manufacturer's printed information leaflet.
  • Take procyclidine exactly as your doctor has told you to. Swallow the tablets with a drink of water.
  • It is not important whether you take procyclidine before or after food, although some people find taking it with meals helps prevent any feelings of sickness.
  • Try to take procyclidine at the same times each day to avoid missing any doses.
  • If you forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case leave out the missed dose. Do not take two doses together to make up for a missed dose.
  • If you have been taking procyclidine for some time, do not stop taking it without speaking with your doctor first. Stopping suddenly can cause problems so your doctor will want to reduce your dose gradually.

Getting the most from your treatment

  • As your condition improves and your body movements become easier, be careful not to overdo physical activities. Physical activities must be increased gradually to allow your body to adjust to changes in balance, circulation and co-ordination. This is especially important if you are over 65 years of age.
  • Keep your regular appointments with your doctor so your progress can be monitored.
  • If you are having any treatment like an operation or dental treatment, tell the person carrying out the treatment that you are taking procyclidine.
  • If you buy any medicines, check with a pharmacist that they are safe to take with your other medicines.

Can procyclidine cause problems?

Along with their useful effects, all medicines can cause unwanted side-effects although not everyone experiences them. These usually improve as your body adjusts to the new medicine, but speak with your doctor or pharmacist if any of the following side-effects continue or become troublesome.

Side-effects What can I do if I experience this
Dry mouth Try chewing sugar-free gum or sugar-free sweets
Constipation Try to eat a well balanced diet containing plenty of fibre, and drink 6-8 glasses of water each day
Blurred vision, dizziness Make sure your reactions are normal before driving, operating machinery or doing any other jobs which could be dangerous if you were not fully alert or able to see properly
Feeling or being sick Eat little and often. Stick to simple foods. Taking procyclidine after meals may help
Difficulty passing urine, a fast heart beat, skin rashes, nervousness, confusion, inflamed gums, and mood changes If any of these become troublesome, let your doctor know

If you experience any other symptoms which you think may be due to this medicine, speak with your doctor or pharmacist.

How to store procyclidine

  • Keep all medicines out of the reach and sight of children.
  • Store in a cool, dry place, away from direct heat and light.