Generic Name: carbinoxamine, hydrocodone, and phenylephrine (kar bi NOX a meen, hy dro KOE done, fen il EFF rin)Brand names: Donatussin MAX, Excof, Excof-SF, Max HC
Carbinoxamine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.
Hydrocodone is a narcotic cough suppressant. It suppresses an area in the brain that causes coughing.
Phenylephrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).
Carbinoxamine, hydrocodone, and phenylephrine is used to treat sneezing, cough, runny or stuffy nose, itchy or watery eyes, hives, skin rash, itching, and other symptoms of allergies and the common cold.
This medication may also be used for purposes other than those listed in this medication guide.
Call your doctor if you have a fever, or if your symptoms get worse or do not improve after taking this medicine for 7 days.
Do not take this product for cough caused by smoking, asthma, or emphysema. Do not take this medicine if your cough produces a lot of mucus, unless your doctor has told you to.Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. This medicine should never be given to another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.
Before taking this medication, tell your doctor if you are allergic to carbinoxamine, hydrocodone, or phenylephrine, or if you have:
a history of drug or alcohol addiction;
heart disease or high blood pressure;
coronary artery disease;
a stomach ulcer or an obstruction in your stomach or intestines;
an enlarged prostate or urination problems;
head injury, brain injury, or brain tumor;
emphysema or chronic bronchitis;
If you have any of these conditions, you may not be able to take this medication, or you may require a dosage adjustment or special monitoring during treatment.FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Carbinoxamine, hydrocodone, and phenylephrine can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from this medicine.
Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.
You may take this medication with or without food.If the medication upsets your stomach, you may take it with food or milk.
Measure the liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist where you can get one.Hydrocodone may cause constipation. Drink 6 to 8 full glasses of water each day while you are taking this medicine. Increasing the amount of fiber in your diet may also help relieve constipation.
Call your doctor if you have a fever, or if your symptoms get worse or do not improve after taking this medicine for 7 days.Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. This medicine should never be given to another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it. Store the medication at room temperature away from moisture and heat.
See also: Carbinoxamine, hydrocodone, and phenylephrine dosage in more detail
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.
Symptoms of an overdose may include dizziness, ringing in the ears, blurred vision, large pupils, dry mouth, a weak heartbeat, extreme drowsiness, sweating, shaking, pale skin, blue lips and fingernails, hallucinations, confusion, seizures, shallow breathing, coma, and death.
Avoid using other medicines that make you sleepy (such as cold medicine, other narcotics, pain medication, muscle relaxers, and medicine for seizures, depression or anxiety). They can add to sleepiness caused by carbinoxamine, hydrocodone, and phenylephrine.
unusual behavior or hallucinations;
an irregular or fast heartbeat;
feeling light-headed, fainting;
urinating less than usual or not at all;
wheezing, tightness in your chest;
fast or pounding heartbeat;
jaundice (yellowing of the skin or eyes);
pale skin, easy bruising or bleeding;
slow or weak breathing; or
swelling, rapid weight gain.
Continue taking this medication and talk to your doctor if you have any of these less serious side effects:
lack of coordination;
upset stomach, nausea, stomach cramps, or constipation;
stuffy nose, chest congestion;
sleep problems (insomnia);
itchy skin rash;
decreased hearing or ringing in the ears;
feeling restless or excited (especially in children);
dry mouth or nose; or
Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome.The hydrocodone in this medication may cause constipation. Drink plenty of water (six to eight full glasses a day) to lessen this side effect. Increasing the amount of fiber in your diet may also help to alleviate constipation.
Usual Adult Dose for Cough and Nasal Congestion:
Carbinoxamine/hydrocodone/phenylephrine 4 mg-5 mg-8 mg/5 mL oral liquid:5 mL orally 3 to 4 times daily.Carbinoxamine/hydrocodone/phenylephrine 2 mg-5 mg-6 mg/5 mL oral liquid:5 to 10 mL orally every 4 to 6 hours, not to exceed 4 doses in 24 hours.
Usual Pediatric Dose for Cough and Nasal Congestion:
Carbinoxamine/hydrocodone/phenylephrine 4 mg-5 mg-8 mg/5 mL oral liquid:>= 12 yrs: 5 mL orally 3 to 4 times daily.>= 6 yrs = 2 yrs = 12 yrs: 5 to 10 mL orally every 4 to 6 hours, not to exceed 4 doses in 24 hours.>= 6 yrs = 3 yrs