Chlorpromazine Suppositories

Generic Name: Chlorpromazine (klor-PROE-ma-zeen)Brand Name: Thorazine

Chlorpromazine Suppositories are used for:

Treating the manic phase of manic-depressive disorder, schizophrenia, anxiety and restlessness before surgery, tetanus, porphyria, severe behavioral and conduct disorders in children, nausea and vomiting, and severe hiccups. It may be used for other conditions as determined by your doctor.

Chlorpromazine Suppositories are a phenothiazine. It works by blocking one of the chemical messengers (dopamine) in the brain. This helps to treat certain mental disorders or prevents or reduces nausea and vomiting due to medicines, chemicals, and some diseases.

Do NOT use Chlorpromazine Suppositories if:

  • you are allergic to any ingredient in Chlorpromazine Suppositories
  • you are in a state of impaired consciousness, unresponsiveness, or coma
  • you are taking an antihistamine (eg, astemizole, terfenadine), an antiarrhythmic agent (eg, quinidine, flecainide), cisapride, dofetilide, a fluoroquinolone (eg, ciprofloxacin), pimozide, a streptogramin (eg, quinupristin), or ziprasidone

Contact your doctor or health care provider right away if any of these apply to you.

Before using Chlorpromazine Suppositories:

Some medical conditions may interact with Chlorpromazine Suppositories. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have or have ever had alcoholism or if you consume more than 3 alcoholic drinks per day
  • if you have increased pressure in the eyes, glaucoma, or are at risk for glaucoma
  • if you have a blood diseases, enlargement of the prostate gland, epilepsy or seizures, heart problems, low blood pressure, liver problems, chronic breathing or lung problems, Parkinson disease, or Reye syndrome

Some MEDICINES MAY INTERACT with Chlorpromazine Suppositories. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Anticholinergics (eg, diphenhydramine, oxybutynin, scopolamine) or anticoagulants (eg, warfarin) because they may decrease Chlorpromazine Suppositories's effectiveness
  • Antihistamines (eg, astemizole, terfenadine), antiarrhythmic agents (eg, quinidine, flecainide), beta-blockers (eg, propranolol), cisapride, dofetilide, droperidol, fluoroquinolones (eg, ciprofloxacin), haloperidol, ketolides (eg, telithromycin), macrolide antibiotics (eg, erythromycin), pimozide, streptogramins (eg, quinupristin), or ziprasidone because the risk of side effects such as racing heartbeat, dizziness, fainting, and life-threatening irregular heartbeat leading to unconsciousness may be increased by Chlorpromazine Suppositories
  • Epinephrine, hydantoins (eg, phenytoin), meperidine, thiazide diuretics (eg, hydrochlorothiazide), or tricyclic antidepressants (eg, amitriptyline) because the risk of their side effects may be increased by Chlorpromazine Suppositories
  • Guanethidine, levodopa, or pergolide because their effectiveness may be decreased by Chlorpromazine Suppositories

This may not be a complete list of all interactions that may occur. Ask your health care provider if Chlorpromazine Suppositories may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Chlorpromazine Suppositories:

Use Chlorpromazine Suppositories as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Wash your hands before and after using Chlorpromazine Suppositories. If the suppository is too soft to use, put it in the refrigerator for about 15 minutes. You may also run cold water over it. Remove the wrapper. Moisten the suppository with cool water. Lie down on your side. Insert the pointed end of the suppository into the rectum. Use your finger to push it in completely.
  • Wash your hands immediately after using Chlorpromazine Suppositories.
  • If you miss a dose of Chlorpromazine Suppositories, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.

Ask your health care provider any questions you may have about how to use Chlorpromazine Suppositories.

Important safety information:

  • Chlorpromazine Suppositories may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Chlorpromazine Suppositories with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Chlorpromazine Suppositories; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
  • Chlorpromazine Suppositories may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Do not become overheated in hot weather or while you are being active; heatstroke may occur.
  • Chlorpromazine Suppositories may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Chlorpromazine Suppositories. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
  • Tell your doctor or dentist that you take Chlorpromazine Suppositories before you receive any medical or dental care, emergency care, or surgery.
  • Some patients who take Chlorpromazine Suppositories may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Chlorpromazine Suppositories in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Chlorpromazine Suppositories.
  • Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Chlorpromazine Suppositories. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
  • Chlorpromazine Suppositories may cause false-positive phenylketonuria (PKU) test results.
  • Lab tests may be performed while you use Chlorpromazine Suppositories. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Chlorpromazine Suppositories with caution in the ELDERLY; they may be more sensitive to its effects, especially dizziness, lightheadedness (especially upon standing), rapid heartbeat, breathing problems, urinary retention, and constipation.
  • Chlorpromazine Suppositories should not be used in CHILDREN younger than 6 months old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Chlorpromazine Suppositories while you are pregnant. Chlorpromazine Suppositories are found in breast milk. Do not breast-feed while taking Chlorpromazine Suppositories.

If you stop taking Chlorpromazine Suppositories suddenly, you may have WITHDRAWAL symptoms. These may include nausea, vomiting, dizziness, and tremors.

Possible side effects of Chlorpromazine Suppositories:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Agitation; blurred vision; constipation; dizziness; drowsiness; dry mouth; enlarged pupils; excessive hunger, thirst, or urination; fever; jitteriness; nausea; neck spasms; sensitivity to light; sexual problems; sleeplessness; stomach pain; stuffy nose; urination problems.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in breasts; changes in menstrual period; difficulty swallowing; drooling; fast or irregular heartbeat; inability to move eyes; increased body heat; infection (fever, chills, sore throat); involuntary movements of the arms and legs; involuntary movements of tongue, face, mouth, or jaw (eg, sticking out of tongue, puffing of cheeks, puckering of mouth, lip-smacking, chewing movements); mask-like face; mental changes, including lack of response to your surroundings; muscle restlessness; muscle spasms; prolonged or painful erection; restlessness; seizures; shuffling walk; stiff or rigid muscles; sweating; tension in legs; unusual eye movements; weakness of arms or legs; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; muscle spasms; restlessness; seizures; tremors; twitching.

Proper storage of Chlorpromazine Suppositories:

Store Chlorpromazine Suppositories at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Chlorpromazine Suppositories out of the reach of children and away from pets.

General information:

  • If you have any questions about Chlorpromazine Suppositories, please talk with your doctor, pharmacist, or other health care provider.
  • Chlorpromazine Suppositories are to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Chlorpromazine Suppositories. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Chlorpromazine Prescribing Information (FDA)
  • Chlorpromazine Detailed Consumer Information (PDR)
  • chlorpromazine Concise Consumer Information (Cerner Multum)