Chlorpromazine (klor-PROE-ma-zeen)Brand Name:
Chlorpromazine are used for:
Treating certain mental or mood disorders (eg, schizophrenia), the manic phase of manic-depressive disorder, anxiety and restlessness before surgery, porphyria, severe behavioral and conduct disorders in children, nausea and vomiting, and severe hiccups. It is also used with other medicines to treat symptoms associated with tetanus. It may also be used for other conditions as determined by your doctor.
Chlorpromazine are a phenothiazine. It works by blocking dopamine receptors in the brain. This helps to treat certain mental disorders or prevents or reduces nausea and vomiting caused by medicines, chemicals, and some diseases.
Do NOT use Chlorpromazine if:
- you are allergic to any ingredient in Chlorpromazine or similar medicines (eg, phenothiazines)
- you have recently taken large amounts of alcohol or CNS depressant medicines, such as barbiturates (eg, phenobarbital) or narcotic pain medicines (eg, codeine)
- you have bone marrow problems or you are taking astemizole, certain antiarrhythmic agents (eg, quinidine), cisapride, dofetilide, a ketolide antibiotic (eg, telithromycin), a macrolide antibiotic (eg, erythromycin), pergolide, pimozide, a streptogramin (eg, dalfopristin), terfenadine, or ziprasidone
Contact your doctor or health care provider right away if any of these apply to you.
Before using Chlorpromazine:
Some medical conditions may interact with Chlorpromazine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a history of heart problems, low blood pressure, blood problems, liver problems (eg, cirrhosis), kidney problems, enlarged prostate gland, seizures or epilepsy, Parkinson disease, or Reye syndrome
- if you have asthma, lung infection, or other lung problems (eg, emphysema); increased pressure in the eyes; glaucoma; or if you are at risk for glaucoma
- if you have a history of alcohol abuse or if you consume more than 3 alcoholic drinks per day
Some MEDICINES MAY INTERACT with Chlorpromazine. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Thiazide diuretics (eg, hydrochlorothiazide) because they may increase the risk of Chlorpromazine's side effects
- Arsenic, astemizole , beta-blockers (eg, propranolol), certain antiarrhythmic agents (eg, quinidine), cisapride, dofetilide, droperidol, epinephrine, haloperidol, ketolides (eg, telithromycin), macrolide antibiotics (eg, erythromycin), pimozide, quinolone antibiotics (eg, ciprofloxacin), streptogramins (eg, quinupristin), terfenadine, or ziprasidone because the risk of side effects, such as racing heartbeat, dizziness, fainting, and life-threatening irregular heartbeat leading to unconsciousness, may be increased by Chlorpromazine
- Anticholinergics (eg, atropine) because they may decrease Chlorpromazine's effectiveness
- Barbiturates (eg, phenobarbital), hydantoins (eg, phenytoin), or narcotic pain medicines (eg, codeine) because the risk of their side effects may be increased by Chlorpromazine
- Anticoagulants (eg, warfarin), guanethidine, and pergolide because their effectiveness may be decreased by Chlorpromazine
This may not be a complete list of all interactions that may occur. Ask your health care provider if Chlorpromazine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Chlorpromazine:
Use Chlorpromazine as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Take Chlorpromazine by mouth with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
- If you miss a dose of Chlorpromazine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Chlorpromazine.
Important safety information:
- Chlorpromazine may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use Chlorpromazine with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do not drink alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Chlorpromazine; it may add to their effects. Ask your pharmacist if you have questions about which medicines may cause drowsiness.
- Chlorpromazine may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
- Do not become overheated in hot weather or while you are being active; heatstroke may occur.
- Chlorpromazine may cause you to become sunburned more easily. Avoid the sun, sunlamps, or tanning booths until you know how you react to Chlorpromazine. Use a sunscreen or wear protective clothing if you must be outside for more than a short time.
- Some patients who take Chlorpromazine may develop muscle movements that they cannot control. This is more likely to happen in elderly patients, especially women. The chance that this will happen or that it will become permanent is greater in those who take Chlorpromazine in higher doses or for a long time. Muscle problems may also occur after short-term treatment with low doses. Tell your doctor at once if you have muscle problems with your arms; legs; or your tongue, face, mouth, or jaw (eg, tongue sticking out, puffing of cheeks, mouth puckering, chewing movements) while taking Chlorpromazine.
- Neuroleptic malignant syndrome (NMS) is a possibly fatal syndrome that can be caused by Chlorpromazine. Symptoms may include fever; stiff muscles; confusion; abnormal thinking; fast or irregular heartbeat; and sweating. Contact your doctor at once if you have any of these symptoms.
- Tell your doctor or dentist that you take Chlorpromazine before you receive any medical or dental care, emergency care, or surgery.
- Lab tests, including liver function tests and eye exams, may be performed while you use Chlorpromazine. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use Chlorpromazine with caution in the ELDERLY; they may be more sensitive to its effects, especially dizziness, light-headedness (especially upon standing), rapid heartbeat, breathing problems, urinary retention, and constipation.
- Chlorpromazine should not be used in CHILDREN younger than 6 months old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Chlorpromazine while you are pregnant. Chlorpromazine are found in breast milk. Do not breast-feed while taking Chlorpromazine.
If you stop taking Chlorpromazine suddenly, you may have WITHDRAWAL symptoms. These may include nausea, vomiting, dizziness, and tremors.
Possible side effects of Chlorpromazine:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Agitation; dizziness; drowsiness; dry mouth; enlarged pupils; jitteriness; nausea; stuffy nose.
Seek medical attention right away if any of these SEVERE side effects occur:
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in menstrual period; changes in sexual ability; dark urine; difficulty swallowing; drooling; fainting; fast or irregular heartbeat; fever, chills, or sore throat; involuntary movements or spasms of the arms and legs, tongue, face, mouth, or jaw; mask-like face; muscle restlessness; prolonged or painful erection; restlessness; seizures; shuffling walk; sleeplessness; stiff or rigid muscles; stomach pain; sweating; trouble urinating; unusual eye movements or inability to move eyes; unusual mood or mental changes, including lack of response to your surroundings; vision changes; weakness of arms or legs; yellowing of the skin or eyes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (http://www.aapcc.org), or emergency room immediately. Symptoms may include deep sleep or loss of consciousness; muscle spasms; restlessness; seizures; tremors; twitching.Proper storage of Chlorpromazine:
Store Chlorpromazine at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Chlorpromazine out of the reach of children and away from pets.
- If you have any questions about Chlorpromazine, please talk with your doctor, pharmacist, or other health care provider.
- Chlorpromazine are to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- If using Chlorpromazine for an extended period of time, obtain refills before your supply runs out.
This information is a summary only. It does not contain all information about Chlorpromazine. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.
- Chlorpromazine Prescribing Information (FDA)
- Chlorpromazine Detailed Consumer Information (PDR)
- chlorpromazine Concise Consumer Information (Cerner Multum)