Ciprofloxacin hydrochloride

Brand names: Proquin XR

Why is Ciprofloxacin hydrochloride prescribed?

ProQuin XR is an antibiotic that belongs to the drug class known as quinolones. It is used to treat adults with simple (uncomplicated) urinary tract infections (also known as bladder infections) caused by bacteria.

Most important fact about Ciprofloxacin hydrochloride

Proquin XR is only used to treat bacterial infections and will not work if taken for a viral infection, such as a cold.

Skipping doses or not completing the full course of Proquin XR therapy may decrease the effectiveness of the treatment and increase the likelihood that bacteria will develop resistance. If the bacteria develop resistance, they will not be treatable by ProQuin XR or other antibacterial drugs in the future.

How should you take Ciprofloxacin hydrochloride?

Take ProQuin XR once a day shortly after a main meal, preferably the evening meal. ProQuin XR does not work as well if you take it without a meal. You should try to take your dose at about the same time each day. Do not crush, split, or chew the tablets.

You should take ProQuin XR for 3 days, even if you start to feel better. If you do not take all 3 daily doses, your infection may not be cured.

Proquin XR should be taken at least 4 hours before or 2 hours after the following medications and supplements:

Antacids containing magnesium or aluminumDidanosine (chewable/buffered tablet or pediatric powder formulations)Calcium, iron, or zinc supplementsSucralfateVitamin/mineral products that contain calcium, iron, or zinc

Do not take ProQuin XR at the same time that you drink milk or juices with added calcium, unless you drink them with a main meal.

  • If you miss a dose...Do not take more than one ProQuin XR tablet a day, even if you miss a dose.
  • Storage instructions...Store at room temperature.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Ciprofloxacin hydrochloride.

  • Side effects may include:Diarrhea, dizziness, headache, nausea, stomach pain, vaginal yeast infection

Why should Ciprofloxacin hydrochloride not be prescribed?

Do not take ProQuin XR if you are allergic to or have ever had a severe reaction to ciprofloxacin or to any other quinolone antibiotic.

Special warnings about Ciprofloxacin hydrochloride

Talk to your doctor about your complete medical history, especially if you have ever had seizures (epilepsy), asthma, or liver or kidney problems.

ProQuin XR may cause dizziness or lightheadedness. Be careful about driving or operating machinery until you know how Ciprofloxacin hydrochloride affects you.

Rare cases of allergic reactions have been reported in patients receiving quinolone antibiotics, including ciprofloxacin, even after just one dose. Stop taking ProQuin XR and seek emergency medical attention immediately if you develop a rash, hives, swelling of your face or throat, or have trouble breathing.

Quinolone antibiotics can make some people more sensitive to sunlight or ultraviolet light such as that used in tanning salons. You should avoid excessive exposure to sunlight or ultraviolet light while taking ProQuin XR.

A type of nerve pain known as peripheral neuropathy has been associated with ciprofloxacin use. If you develop symptoms of this problem—including sensitivity to touch, burning sensations, tingling, numbness, or muscle weakness—contact your doctor immediately.

Rarely, ciprofloxacin has been associated with inflammation of the tendons. Stop taking ProQuin XR and call your doctor if you experience pain, swelling, or rupture of a tendon.

Convulsions have been reported in people receiving quinolone antibiotics, including ciprofloxacin. Tell your doctor if you have had convulsions or seizures in the past.

Quinolone antibiotics, including ciprofloxacin, have been rarely associated with central nervous system problems such as confusion, tremors, hallucinations, and depression. Stop taking ProQuin XR and call your doctor right away if you experience any of these problems.

Possible food and drug interactions when taking Ciprofloxacin hydrochloride

Tell your doctor about all medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. If Proquin XR is taken with certain other drugs or supplements, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Proquin XR with the following:

Antacids containing magnesium or aluminumCaffeineCalcium, iron, or zinc supplementsDidanosineGlyburidePhenytoinSucralfateTheophyllineVitamin/mineral products that contain calcium, iron, or zincWarfarin

Do not take ProQuin XR at the same time that you drink milk or juices with added calcium, unless you drink them with a main meal.

Special information if you are pregnant or breastfeeding

The effects of Proquin XR during pregnancy and breastfeeding are unknown. Talk with your doctor before taking Ciprofloxacin hydrochloride if you are pregnant, plan to become pregnant, or are breastfeeding.

Recommended dosage for Ciprofloxacin hydrochloride


The dosage is one 500-milligram tablet taken once a day for 3 days. Take ProQuin XR with the main meal of the day (see "How to take Ciprofloxacin hydrochloride").


Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.

  • Ciprofloxacin Prescribing Information (FDA)
  • Ciprofloxacin Professional Patient Advice (Wolters Kluwer)
  • Cipro Consumer Overview
  • Cipro MedFacts Consumer Leaflet (Wolters Kluwer)
  • Cipro Advanced Consumer (Micromedex) - Includes Dosage Information
  • Cipro Prescribing Information (FDA)
  • Cipro I.V. MedFacts Consumer Leaflet (Wolters Kluwer)
  • Cipro XR Prescribing Information (FDA)
  • Cipro XR Extended-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)
  • Proquin XR Prescribing Information (FDA)
  • Proquin XR Extended-Release Tablets MedFacts Consumer Leaflet (Wolters Kluwer)
  • Proquin XR Consumer Overview