Clomiphene Citrate

Brand names: Clomid

Why is Clomiphene Citrate prescribed?

Clomiphene is prescribed for the treatment of ovulatory failure in women who wish to become pregnant and whose husbands are fertile and potent.

Most important fact about Clomiphene Citrate

Properly timed sexual intercourse is very important to increase the chances of conception. The likelihood of conception diminishes with each succeeding course of treatment. Your doctor will determine the need for continuing therapy after the first course. If you do not ovulate after 3 courses or do not become pregnant after 3 ovulations, your doctor will stop the therapy.

How should you take Clomiphene Citrate?

Take Clomiphene Citrate exactly as prescribed by your doctor.

--If you miss a dose...

Take it as soon as you remember. If it is time for your next dose, take the 2 doses together and go back to your regular schedule. If you miss more than 1 dose, contact your doctor.

--Storage instructions...

Store at room temperature in a tightly closed container, away from light, moisture, and excessive heat.

Clomiphene Citrate side effects

Side effects occur infrequently and generally do not interfere with treatment at the recommended dosage of clomiphene. They tend to occur more frequently at higher doses and during long-term treatment.

  • Side effects include:Abdominal discomfort, enlargement of the ovaries, hot flushes

Why should Clomiphene Citrate not be prescribed?

If you are pregnant or think you may be, do not take Clomiphene Citrate.

Unless directed to do so by your doctor, do not use Clomiphene Citrate if you have an uncontrolled thyroid or adrenal gland disorder, an abnormality of the brain such as a pituitary gland tumor, a liver disease or a history of liver problems, abnormal uterine bleeding of undetermined origin, ovarian cysts, or enlargement of the ovaries not caused by polycystic ovarian syndrome (a hormonal disorder causing lack of ovulation).

Special warnings about Clomiphene Citrate

Your doctor will evaluate you for normal liver function and normal estrogen levels before considering you for treatment with clomiphene.

Your doctor will also examine you for pregnancy, ovarian enlargement, or cyst formation prior to treatment with Clomiphene Citrate and between each treatment cycle. He or she will do a complete pelvic examination before each course of Clomiphene Citrate.

Clomiphene treatment increases the possibility of multiple births; also, birth defects have been reported following treatment to induce ovulation with clomiphene, although no direct effects of the drug on the unborn child have been established.

Because blurring and other visual symptoms may occur occasionally with clomiphene treatment, you should be cautious about driving a car or operating dangerous machinery, especially under conditions of variable lighting.

If you experience visual disturbances, notify your doctor immediately. Symptoms of visual disturbance may include blurring, spots or flashes, double vision, intolerance to light, decreased visual sharpness, loss of peripheral vision, and distortion of space. Your doctor may recommend a complete evaluation by an eye specialist.

Ovarian hyperstimulation syndrome (or OHSS, enlargement of the ovary) has occurred in women receiving treatment with clomiphene. OHSS may progress rapidly and become serious. The early warning signs are severe pelvic pain, nausea, vomiting, and weight gain. Symptoms include abdominal pain, abdominal enlargement, nausea, vomiting, diarrhea, weight gain, difficult or labored breathing, and less urine production. If you experience any of these warning signs or symptoms, notify your doctor immediately.

To lessen the risks associated with abnormal ovarian enlargement during treatment with clomiphene, the lowest effective dose should be prescribed. Women with the hormonal disorder, polycystic ovarian syndrome, may be unusually sensitive to certain hormones and may respond abnormally to usual doses of Clomiphene Citrate. If you experience pelvic pain, notify your doctor. He may discontinue your use of clomiphene until the ovaries return to pretreatment size.

Because the safety of long-term treatment with clomiphene has not been established, your doctor will not prescribe more than about 6 courses of therapy. Prolonged use may increase the risk of a tumor in the ovaries.

Possible food and drug interactions when taking Clomiphene Citrate

No food or drug interactions have been reported.

Special information if you are pregnant or breastfeeding

If you become pregnant, notify your doctor immediately. You should not be taking Clomiphene Citrate while you are pregnant.

Recommended dosage for Clomiphene Citrate

The recommended dosage for the first course of treatment is 50 milligrams (1 tablet) daily for 5 days. If ovulation does not appear to have occurred, your doctor may try up to 2 more times.


Taking any medication in excess can have serious consequences. If you suspect an overdose of clomiphene, contact your doctor immediately.

  • Clomid Prescribing Information (FDA)
  • Clomid Consumer Overview
  • Clomid Advanced Consumer (Micromedex) - Includes Dosage Information
  • Clomid MedFacts Consumer Leaflet (Wolters Kluwer)
  • Clomiphene Prescribing Information (FDA)
  • Serophene Prescribing Information (FDA)