Clotrimazole/Betamethasone Cream

Generic Name: Clotrimazole/Betamethasone (kloe-TRIM-a-zole/BAY-ta-METH-a-sone)Brand Name: Lotrisone

Clotrimazole/Betamethasone Cream is used for:

Treating certain fungal skin infections, including ringworm, athlete's foot, and jock itch. It also relieves redness, swelling, and itching associated with infection.

Clotrimazole/Betamethasone Cream is an antifungal and corticosteroid combination. It works by weakening the cell membrane of certain fungi. It also acts as an anti-inflammatory and anti-itching agent.

Do NOT use Clotrimazole/Betamethasone Cream if:

  • you are allergic to any ingredient in Clotrimazole/Betamethasone Cream
  • you are taking pimozide or an ergot alkaloid (eg, ergotamine)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Clotrimazole/Betamethasone Cream:

Some medical conditions may interact with Clotrimazole/Betamethasone Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines or other substances
  • if you have diaper rash, eczema, measles, tuberculosis (TB) or a positive TB skin test, chickenpox, shingles, or thinning of the skin
  • if you have recently received a vaccination

Some MEDICINES MAY INTERACT with Clotrimazole/Betamethasone Cream. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Clarithromycin because the risk of certain side effects may be increased
  • Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), or rifampin because they may decrease Clotrimazole/Betamethasone Cream's effectiveness
  • Ergot alkaloids (eg, ergotamine), imatinib, live vaccines, macrolide immunosuppressants (eg, tacrolimus), pimozide, or ritodrine because their actions and the risk of their side effects may be increased by Clotrimazole/Betamethasone Cream
  • Hydantoins (eg, phenytoin) or interleukin-2 because their effectiveness may be decreased by Clotrimazole/Betamethasone Cream

This may not be a complete list of all interactions that may occur. Ask your health care provider if Clotrimazole/Betamethasone Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Clotrimazole/Betamethasone Cream:

Use Clotrimazole/Betamethasone Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Wash your hands before and after applying Clotrimazole/Betamethasone Cream.
  • Wash and completely dry the affected area.
  • Gently rub the medicine into the affected and surrounding areas until it is evenly distributed.
  • Do not bandage or wrap the affected area unless directed otherwise by your doctor.
  • If you are using Clotrimazole/Betamethasone Cream in the groin area, use only for 2 weeks and apply the cream sparingly. Wear loose-fitting clothing. Notify your doctor if your condition persists after 2 weeks.
  • Use Clotrimazole/Betamethasone Cream on a regular schedule to get the most benefit from it.
  • To clear up your infection completely, use Clotrimazole/Betamethasone Cream for the full course of treatment. Keep using it even if you feel better in a few days.
  • Notify your doctor if there is no improvement of your symptoms after 1 week of treatment on the groin or body or after 2 weeks of treatment on the feet.
  • If you miss a dose of Clotrimazole/Betamethasone Cream, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Ask your health care provider any questions you may have about how to use Clotrimazole/Betamethasone Cream.

Important safety information:

  • Clotrimazole/Betamethasone Cream has a corticosteroid in it. Before you start any new medicine, check the label to see if it has a corticosteroid in it too. If it does or if you are not sure, check with your doctor or pharmacist.
  • Clotrimazole/Betamethasone Cream is for external use only. Avoid getting Clotrimazole/Betamethasone Cream in the eyes, vagina, mouth, or nose. If Clotrimazole/Betamethasone Cream gets in the eyes, immediately wash out with cool tap water.
  • Be sure to use Clotrimazole/Betamethasone Cream for the full course of treatment. If you do not, the medicine may not clear up your infection completely. The fungus could also become less sensitive to this or other medicines. This could make the infection harder to treat in the future.
  • Do NOT use more than the recommended dose or use for longer than prescribed without checking with your doctor.
  • Do not apply Clotrimazole/Betamethasone Cream over large areas of the body without first checking with your doctor.
  • Do not use Clotrimazole/Betamethasone Cream for other skin conditions at a later time.
  • Talk with your doctor before you use any other medicines or cleansers on your skin.
  • Do not use Clotrimazole/Betamethasone Cream for diaper rash.
  • Serious side effects may occur if too much of Clotrimazole/Betamethasone Cream is absorbed through the skin. This may be more likely to occur if you use Clotrimazole/Betamethasone Cream over a large area of the body. It may also be more likely if you wrap or bandage the area after you apply Clotrimazole/Betamethasone Cream. The risk is greater in children. Do not use more than the prescribed dose. Contact your doctor right away if you develop unusual weight gain (especially in the face), muscle weakness, increased thirst or urination, confusion, unusual drowsiness, severe or persistent headache, or vision changes. Discuss any questions or concerns with your doctor.
  • Use Clotrimazole/Betamethasone Cream with caution in the ELDERLY; they may be more sensitive to its effects, especially thinning skin.
  • Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while using a corticosteroid.
  • Clotrimazole/Betamethasone Cream should not be used in CHILDREN younger than 17 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Clotrimazole/Betamethasone Cream while you are pregnant. It is not known if Clotrimazole/Betamethasone Cream is found in breast milk. If you are or will be breast-feeding while you use Clotrimazole/Betamethasone Cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Clotrimazole/Betamethasone Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dry skin; mild burning or stinging at the application site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); acne-like rash; excessive hair growth; inflamed hair follicles; inflammation around the mouth; irritation, itching, peeling, redness, blistering, swelling, oozing, or severe burning at the application site; spider veins; thinning, softening, or discoloration of the skin; unusual bruising.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Clotrimazole/Betamethasone Cream may be harmful if swallowed.

Proper storage of Clotrimazole/Betamethasone Cream:

Store Clotrimazole/Betamethasone Cream at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Clotrimazole/Betamethasone Cream out of the reach of children and pets.

General information:

  • If you have any questions about Clotrimazole/Betamethasone Cream, please talk with your doctor, pharmacist, or other health care provider.
  • Clotrimazole/Betamethasone Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is summary only. It does not contain all information about Clotrimazole/Betamethasone Cream. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.