Generic Name: Colchicine/Probenecid (KOL-chi-seen/proe-BEN-e-sid)Brand Name: Generic only. No brands available.

Colchicine/Probenecid is used for:

Treating long-term gouty arthritis that is complicated by frequent attacks of gout. It may also be used for other conditions as determined by your doctor.

Colchicine/Probenecid is a combination antigout and uricosuric agent. The uricosuric agent works by increasing the excretion of uric acid from the body. Exactly how the antigout agent works is unknown.

Do NOT use Colchicine/Probenecid if:

  • you are allergic to any ingredient in Colchicine/Probenecid
  • you have certain blood problems or kidney stones caused by uric acid
  • you are pregnant
  • the patient is a child younger than 2 years old
  • you are taking a salicylate (eg, aspirin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Colchicine/Probenecid :

Some medical conditions may interact with Colchicine/Probenecid . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have liver or kidney problems, kidney stones, high levels of uric acid in the urine, stomach or intestinal problems (eg, ulcer, spastic colon), heart problems, blood problems, diabetes, or glucose-6-phosphate dehydrogenase deficiency
  • if you are undergoing radiation therapy

Some MEDICINES MAY INTERACT with Colchicine/Probenecid . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Fluvastatin because the risk of muscle problems may be increased
  • Acidifying agents (eg, ammonium chloride), pyrazinamide, or salicylates (eg, aspirin) because they may decrease Colchicine/Probenecid 's effectiveness
  • Macrolides (eg, erythromycin) because they may increase the risk of Colchicine/Probenecid 's side effects
  • Acetaminophen, beta lactam antibiotics (eg, imipenem), cephalosporins (eg, cephalexin), certain anesthesias (eg, ketamine, thiopental), certain stimulants (eg, epinephrine), ganciclovir, indomethacin, lorazepam, methotrexate, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen, ketoprofen), penicillins (eg, amoxicillin), rifampin, sulfonamides (eg, sulfamethoxazole), sulfonylureas (eg, glipizide), theophyllines (eg, dyphylline), or zidovudine because the risk of their side effects may be increased by Colchicine/Probenecid

This may not be a complete list of all interactions that may occur. Ask your health care provider if Colchicine/Probenecid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Colchicine/Probenecid :

Use Colchicine/Probenecid as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take Colchicine/Probenecid by mouth with or without food.
  • You should not start taking Colchicine/Probenecid if you are currently having a gout attack. Wait until the gout attack stops to begin taking Colchicine/Probenecid , unless directed otherwise by your doctor. If you are already taking Colchicine/Probenecid , you may continue to take it during a gout attack unless your doctor tells you otherwise.
  • Drinking extra fluids while you are taking Colchicine/Probenecid is recommended. Check with your doctor for instructions.
  • Talk with your doctor before eating grapefruit or drinking grapefruit juice while taking Colchicine/Probenecid .
  • If you miss a dose of Colchicine/Probenecid , take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Colchicine/Probenecid .

Important safety information:

  • Colchicine/Probenecid may cause dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use Colchicine/Probenecid with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Follow the diet and exercise program given to you by your health care provider.
  • Tell your doctor or dentist that you take Colchicine/Probenecid before you receive any medical or dental care, emergency care, or surgery.
  • Diabetes patients - Colchicine/Probenecid may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Colchicine/Probenecid may interfere with certain lab tests, including blood or hemoglobin urine tests and theophylline tests. Be sure your doctor and lab personnel know you are taking Colchicine/Probenecid .
  • Lab tests, including tests for sugar in the urine, may be performed while you use Colchicine/Probenecid . These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Colchicine/Probenecid should not be used in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use Colchicine/Probenecid if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Colchicine/Probenecid is found in breast milk. If you are or will be breast-feeding while you use Colchicine/Probenecid , check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Colchicine/Probenecid :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; flushing; hair loss; headache; loss of appetite; nausea; sore gums; stomach pain; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in the urine; chills; dark urine; decreased or increased urination; fever; infection; lower back, lower stomach, genital, or inner thigh pain; muscle weakness; numbness or tingling; severe diarrhea; severe or persistent nausea or vomiting; sore throat; tiredness; unusual bleeding or bruising; weakness; worsening gout; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include burning pain in throat, stomach, and skin; muscle weakness; severe diarrhea; severe or persistent nausea, stomach pain, or vomiting.

Proper storage of Colchicine/Probenecid :

Store Colchicine/Probenecid at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Colchicine/Probenecid out of the reach of children and away from pets.

General information:

  • If you have any questions about Colchicine/Probenecid , please talk with your doctor, pharmacist, or other health care provider.
  • Colchicine/Probenecid is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is summary only. It does not contain all information about Colchicine/Probenecid . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.