Conjugated Estrogens Cream

Generic Name: Conjugated Estrogens (KON-joo-GAY-ted ES-troe-jenz)Brand Name: Premarin

Conjugated Estrogens Cream increases the chances of getting cancer of the uterus. Report any unusual vaginal bleeding right away while using Conjugated Estrogens Cream. Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your health care provider should check any unusual vaginal bleeding to find out the cause.

Do not use Conjugated Estrogens Cream with or without progestins (eg, medroxyprogesterone) to prevent heart disease, heart attacks, strokes, or dementia. Using estrogens with or without progestins may increase your chances of getting heart attacks, strokes, breast cancer, and blood clots. Using estrogens with or without progestins may increase your risk of dementia, based on a study of women 65 years of age or older. You and your health care provider should talk regularly about whether you still need treatment with Conjugated Estrogens Cream.

Conjugated Estrogens Cream is used for:

Treating certain menopausal changes of the vagina (eg, vaginal dryness) and other vaginal conditions. It is also used to treat painful intercourse caused by those vaginal changes. It may also be used for certain conditions as determined by your doctor.

Conjugated Estrogens Cream is a mixture of female estrogen hormones. It works by replacing natural estrogens in a woman who can no longer produce enough estrogen.

Do NOT use Conjugated Estrogens Cream if:

  • you are allergic to any ingredient in Conjugated Estrogens Cream
  • you are pregnant or suspect you may be pregnant
  • you have known, suspected, or a history of breast cancer (unless directed by your doctor) or other cancers that are estrogen-dependent
  • you have abnormal vaginal bleeding of unknown cause
  • you have liver problems or liver disease, or the blood disease porphyria
  • you have recently (within the last year) had a stroke or heart attack
  • you have blood clots or circulation disorders

Contact your doctor or health care provider right away if any of these apply to you.

Before using Conjugated Estrogens Cream:

Some medical conditions may interact with Conjugated Estrogens Cream. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have an abnormal mammogram
  • if you have asthma (wheezing), a benign breast nodule, bone cancer, depression, diabetes, endometriosis or endometrial (uterine) cancer, epilepsy (seizures), gallbladder disease, heart problems, high blood pressure, kidney problems, liver problems or a history of yellowing of the skin or eyes, lupus, migraines, obesity, pancreatitis, uterine fibroids, thyroid problems, or you have high calcium levels in your blood
  • if you use tobacco, you are going to have surgery, or you will be on bed rest
  • if you have a personal or family history of high cholesterol, lipid, calcium, or triglyceride levels; or breast cancer

Some MEDICINES MAY INTERACT with Conjugated Estrogens Cream. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Clarithromycin, erythromycin, itraconazle, ketoconazole, or ritonavir because they may increase the risk of Conjugated Estrogens Cream's side effects.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Conjugated Estrogens Cream may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Conjugated Estrogens Cream:

Use Conjugated Estrogens Cream as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Conjugated Estrogens Cream. Talk to your pharmacist if you have questions about this information.
  • Closely follow the dosing schedule provided by your doctor. On days that you are using Conjugated Estrogens Cream, use it at the same time each day.
  • Wash your hands before and after using Conjugated Estrogens Cream.
  • Fill the applicator with Conjugated Estrogens Cream according to the directions provided. Lie on your back with your knees drawn up, insert the applicator high into the vagina, and press the plunger to release the medicine.
  • To clean the applicator, pull the plunger to remove it from the barrel. Wash with mild soap and warm water and rinse well. Do not boil or use hot water.
  • Discuss with your doctor stopping Conjugated Estrogens Cream 4 to 6 weeks before surgery.
  • Eating grapefruit or drinking grapefruit juice may increase the risk of side effects. Check with your doctor before including grapefruit or grapefruit juice in your diet.
  • If you miss a dose of Conjugated Estrogens Cream, take it as soon as possible. If it is almost time for the next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Conjugated Estrogens Cream.

Important safety information:

  • Conjugated Estrogens Cream may cause dizziness. This effect may be worse if you take it with alcohol or certain medicines. Use Conjugated Estrogens Cream with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Conjugated Estrogens Cream may increase the risk of stroke, blood clots, high blood pressure, or similar problems. The risk may be greater if you smoke (especially in women older than 35 years of age).
  • Before using Conjugated Estrogens Cream, you will need to have a complete medical and family history exam, which will include blood pressure, breast, stomach, and pelvic organ exams and a Pap smear.
  • You should have periodic mammograms as determined by your doctor. Follow your doctor's instructions for examining your own breasts, and report any lumps immediately.
  • Your doctor should reevaluate you every 3 to 6 months to determine whether or not you need to continue taking Conjugated Estrogens Cream.
  • If you are only being treated for vaginal menopause symptoms, products applied locally, such as vaginal creams, tablets, or rings, should be considered before products taken by mouth or absorbed through the skin. If you have other medical conditions and are prescribed estrogens for more than one condition, consult your doctor about your treatment plan and its options.
  • Conjugated Estrogens Cream may weaken and increase the failure of condoms, diaphragms, or cervical caps made of latex or rubber. If you may become pregnant, use another form of birth control.
  • Diabetes patients - Conjugated Estrogens Cream may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Conjugated Estrogens Cream may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker, and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
  • If you wear contact lenses and you develop problems with them, contact your doctor.
  • If you will be having surgery or will be on bedrest, notify your doctor beforehand. Special precautions may need to be taken in these circumstances while you are taking Conjugated Estrogens Cream.
  • Conjugated Estrogens Cream may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using Conjugated Estrogens Cream.
  • Lab tests, including a lipid profile or thyroid function, may be performed while you use Conjugated Estrogens Cream. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use Conjugated Estrogens Cream with caution in ELDERLY women; they may be more sensitive to its effects.
  • Conjugated Estrogens Cream should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Do not use Conjugated Estrogens Cream if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Conjugated Estrogens Cream is found in breast milk. If you are or will be breast-feeding while you use Conjugated Estrogens Cream, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Conjugated Estrogens Cream:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Back pain; bloating; breast pain or tenderness; diarrhea; dizziness; headache; increased cough; increased or decreased interest in sex; irregular vaginal bleeding or spotting; lightheadedness; mild hair loss; mild vaginal burning, itching, or irritation; muscle aches or cramps; nausea; sore throat; stomach pain or cramping; trouble sleeping; vomiting; weakness; weight changes.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); breast lumps; changes in vision or speech; chest pain; confusion; dark urine; depression; fainting; fever, chills or persistent sore throat; mental or mood changes; one-sided weakness; pain or tenderness in the calves; persistent pain or tenderness in the upper abdomen; severe or persistent dizziness or headache; severe or persistent stomach or back pain with nausea or vomiting; sudden shortness of breath; swelling of the hands or feet; unusual vaginal bleeding or discharge, itching, or odor; weakness or numbness of an arm or leg; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include excessive vaginal bleeding 2 to 7 days following overdose; severe nausea and vomiting.

Proper storage of Conjugated Estrogens Cream:

Store Conjugated Estrogens Cream at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Conjugated Estrogens Cream out of the reach of children and away from pets.

General information:

  • If you have any questions about Conjugated Estrogens Cream, please talk with your doctor, pharmacist, or other health care provider.
  • Conjugated Estrogens Cream is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Conjugated Estrogens Cream. Additionally, your doctor may have prescribed Conjugated Estrogens Cream for a use not mentioned above. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

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