Cordilox MR tablets contain the active ingredient verapamil, which is a type of medicine called a calcium-channel blocker. This type of medicine acts on the heart and blood vessels. (NB. Verapamil is also available without a brand name, ie as the generic medicine.)
Verapamil works by slowing down the movement of calcium through muscle cells that are found in the heart and the walls of blood vessels. It does this by blocking 'calcium channels' on these muscle cells. Calcium is needed by the muscle cells in order for them to contract. By depriving them of calcium, verapamil causes the muscle cells to relax. This action of verapamil has two main effects; it slows down the rate at which the heart beats and it allows the blood vessels in the body to widen.
When the heart beats more slowly, the pressure at which the blood is pumped out of the heart is reduced. When the blood vessels in the body relax and widen, this decreases the resistance that the heart has to push against in order to pump the blood around the body. Both these actions reduce the pressure within the blood vessels. This means verapamil can be used to lower high blood pressure.
Slowing the heart rate also reduces the energy used by the heart to pump blood around the body. This in turn reduces the heart's need for oxygen. At the same time, widening the blood vessels improves the blood and therefore oxygen supply to the heart. Both these features mean that verapamil can be used in the management of angina.
The chest pain of angina is caused by insufficient oxygen supply to the heart. As verapamil improves this oxygen supply, and also reduces the effort the heart has to make to pump blood, it can be used to prevent angina attacks.
Cordilox MR tablets are a long-acting or 'modified-release' form of verapamil. This means that they are designed to release the verapamil slowly and continuously over several hours to produce a steady blood level of the medicine throughout the day.
This medicine should not be used if you are allergic to any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.
If verapamil is used in combination with other medicines that lower blood pressure, either to treat high blood pressure (antihypertensives), or as a side effect, the combination might lower your blood pressure too much. This could make you feel dizzy or faint, particularly when moving from a lying or sitting position to sitting or standing. This is more likely when you first start taking verapamil with one of these medicines. If you feel dizzy or faint you should sit or lie down until the symptoms pass. Tell your doctor if any dizziness persists, as your medicine doses may need adjusting. Other medicines that decrease blood pressure include the following:
There may be an increased risk of a slowed heart rate, low blood pressure and heart failure if beta-blockers (for example atenolol, propranolol, timolol) are used in combination with verapamil. Beta-blocker eye drops (used to treat glaucoma) have also been reported to have this effect. It is recommended that beta-blockers are not given by injection to people taking verapamil.
There may be an increased risk of a slowed heart rate, low blood pressure and heart failure if medicines for irregular heartbeats (antiarrhythmics, for example amiodarone, disopyramide, flecainide) are used in combination with verapamil.
Verapamil may decrease the breakdown of the following medicines by the liver and may therefore increase the amount of these medicines in the blood. As this could increase the risk of their side effects, your doctor may need to reduce your dose of these medicines if you take them in combination with verapamil:
The following medicines may increase the blood level of verapamil. If you take any of these with verapamil, you should tell your doctor if you feel dizzy or experience any other side effects, as the dose of your verapamil may need to be reduced:
The following medicines may increase the removal of verapamil from the body and could therefore make it less effective. If you take any of these in combination with verapamil your doctor may need to increase your verapamil dose:
If verapamil is taken in combination with lithium the level of lithium in the blood may decrease, which could make it less effective. However, there may also be increased sensitivity to lithium, which could increase the risk of its side effects. Combined use should be well monitored by your doctor. If you take these medicines together it is important to tell your doctor if you experience any new or increased signs of lithium side effects.
The following medicines may reduce the blood pressure lowering effect of this medicine:
|Securon IV||Securon SR||Univer|
|Verapress MR||Vertab SR||Zolvera|
Verapamil standard release tablets and oral solution are available without a brand name, ie as the generic medicine.