Cortenema Enema

Generic Name: Hydrocortisone (HYE-droe-KOR-ti-sone)Brand Name: Examples include Colocort and Cortenema

Cortenema Enema is used for:

Treating inflammatory conditions of the colon such as ulcerative colitis and ulcerative proctitis. It may also be used for other conditions as determined by your doctor.

Cortenema Enema is a topical corticosteroid. It works by decreasing inflammation.

Do NOT use Cortenema Enema if:

  • you are allergic to any ingredient in Cortenema Enema
  • you are taking interleukin-2 or mifepristone, or you will be receiving a smallpox vaccine
  • you have a rectal obstruction, abscess, or perforation; recent colostomy surgery; or a systemic fungal infection

Contact your doctor or health care provider right away if any of these apply to you.

Before using Cortenema Enema:

Some medical conditions may interact with Cortenema Enema. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a weakened immune system; a parasitic, bacterial, fungal, or viral infection; heart failure; diabetes; diarrhea; swelling of the esophagus; stomach problems; blockage of the bowel or other bowel problems; abnormal blood electrolyte (eg, potassium, sodium) levels; measles; tuberculosis (TB); chickenpox; shingles; or herpes infection of the eye; or if you have received a recent vaccination
  • if you have a history of glaucoma, cataracts, or other eye problems; high blood pressure; weak bones; heart attack; ulcers; kidney problems; liver problems (eg, cirrhosis); underactive thyroid; nerve problems (eg, myasthenia gravis); or a positive TB skin test

Some MEDICINES MAY INTERACT with Cortenema Enema. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Aprepitant, clarithromycin, or hormonal contraceptives (eg, birth control pills) because they may increase the risk of Cortenema Enema's side effects
  • Barbiturates (eg, phenobarbital), carbamazepine, hydantoins (eg, phenytoin), or rifampin because they may decrease Cortenema Enema's effectiveness
  • Anticoagulants (eg, warfarin), ritodrine, or smallpox vaccine because the risk of their side effects may be increased by Cortenema Enema
  • Interleukin-2 or mifepristone because their effectiveness may be decreased by Cortenema Enema

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cortenema Enema may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Cortenema Enema:

Use Cortenema Enema as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet is available with Cortenema Enema. Talk to your pharmacist if you have questions about this information.
  • Shake well before each use.
  • Wash your hands immediately after using Cortenema Enema.
  • Use Cortenema Enema on a regular schedule to get the most benefit from it. Using it at the same time each day (usually at bedtime or as directed by your doctor) will help you remember to use it.
  • Do not suddenly stop using Cortenema Enema if your course of treatment lasts longer than 21 days. Your doctor will gradually lower your dose.
  • If you miss a dose of Cortenema Enema and you are using it regularly, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Ask your health care provider any questions you may have about how to use Cortenema Enema.

Important safety information:

  • Do not use Cortenema Enema for other rectal conditions at a later time.
  • Tell your doctor or dentist that you take Cortenema Enema before you receive any medical or dental care, emergency care, or surgery.
  • Do not receive a live vaccine (eg, measles, mumps) while you are taking Cortenema Enema. Talk with your doctor before you receive any vaccine.
  • If you have not had chickenpox, shingles, or measles, avoid contact with anyone who does. If you are exposed to someone who has one of these conditions, contact your doctor right away.
  • If your symptoms do not get better within 2 to 3 weeks or if they get worse, check with your doctor.
  • Cortenema Enema should be used with extreme caution in CHILDREN; safety and effectiveness in children have not been confirmed.
  • Corticosteroids may affect growth rate in CHILDREN and teenagers in some cases. They may need regular growth checks while they use Cortenema Enema.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Cortenema Enema while you are pregnant. It is not known if Cortenema Enema is found in breast milk. If you are or will be breast-feeding while you use Cortenema Enema, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of Cortenema Enema:

All medicines may cause side effects, but many people have no, or minor side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild irritation or dryness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); fever, chills, or persistent sore throat; mental or mood changes; new or worsening rectal pain, burning, itching, bleeding, or irritation; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Cortenema Enema may be harmful if swallowed.

Proper storage of Cortenema Enema:

Store Cortenema Enema at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cortenema Enema out of the reach of children and away from pets.

General information:

  • If you have any questions about Cortenema Enema, please talk with your doctor, pharmacist, or other health care provider.
  • Cortenema Enema is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Cortenema Enema. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

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