Cubicin is an antibiotic used in adults to treat:
Cubicin will not work against infections that cause pneumonia (a serious infection or inflammation in the lung tissue).
Cubicin is an antibiotic that belongs to a group of medicines called cyclic lipopeptides. These antibiotics work by killing the Gram-positive bacteria that are causing your infection.
Ask your doctor if you have any questions about why Cubicin has been prescribed for you.
Your doctor may have prescribed it for another purpose.
This medicine is available only with a doctor's prescription.
Cubicin is not addictive.
You must not have Cubicin if you are allergic (hypersensitive) to daptomycin, the active ingredient, or to any of the other ingredients listed at the end of this leaflet.
Some of the symptoms of an allergic reaction may include shortness of breath, wheezing or difficulty breathing; swelling of the face, lips, tongue or other parts of the body; rash, itching or hives on the skin.
You must not have this medicine after the expiry date printed on the pack or if the packaging is torn or shows signs of tampering.
In that case, it should be returned to your pharmacist.
This medicine is not to be given to a child under the age of 18 years.
There is not enough information to recommend the use of this medicine for children under the age of 18 years.
Tell your doctor if you:
Tell your doctor if you are taking, or have recently taken, any other medicines, including medicines that you buy without a prescription from a pharmacy, supermarket or health food shop.
Some medicines and Cubicin may interfere with each other.
Tell your doctor if you are taking:
These medicines may be affected by Cubicin, or may affect how well it works. You may need different amounts of your medicines, or you may need to take different medicines. Your doctor and pharmacist have more information.
If you have not told your doctor about any of these things, tell him/her before you are given this medicine.
Your medicine will be given to you by a doctor or a nurse as it needs to be given as an injection or infusion into a vein.
Your doctor will decide what dose and how long you will receive Cubicin. The dose will depend on how much you weigh and the type of infection being treated. The usual adult dose is 4 mg/kg daily for skin infections and 6mg/kg daily for blood or heart infections.
If you are over 65 years of age, you will be given the same dose as other adults, provided your kidneys are working well.
Cubicin is given directly into your blood stream by intravenous injection over about 2 minutes or by infusion (drip) over about 30 minutes.
Your doctor will determine when you are given Cubicin.
A course of treatment usually lasts for 7 to 14 days for skin infections and 2 to 6 weeks for blood or heart infections. Your doctor will decide how long you should be treated.
If you have kidney problems, you may receive Cubicin less often, e.g. every other day. If you are receiving dialysis, and your next dose of Cubicin is due on a dialysis day, you will usually be given Cubicin after the dialysis session.
If you think that you have missed a dose of treatment, tell a doctor or nurse or pharmacist at once.
Since Cubicin is given by a doctor or nurse, once a day, it is very unlikely that you will miss a dose.
Immediately telephone your doctor, or the Poisons Information Centre (telephone 13 11 26) or go to Accident and Emergency at your nearest hospital, if you think that you may have been given too much Cubicin. Do this even if there are no signs of discomfort or poisoning.
Since Cubicin is given by a doctor or nurse, once a day, it is very unlikely that you will be given too much of the medicine. Your doctor, nurse or pharmacist will be monitoring your progress and checking the medicine that you are given.
If the symptoms of your infection do not improve, or if they become worse, tell your doctor.
If you develop itching with swelling or skin rash or difficulty breathing while you are being given Cubicin contact your doctor immediately.
Tell your doctor immediately if you develop any of the following symptoms:
Your doctor will perform blood tests to monitor the health of your muscles both before you start treatment , and frequently during the course of treatment with Cubicin.
Your doctor will monitor your kidney function and the health of your muscles more frequently during Cubicin treatment if you have kidney problems.
If you get a sore white mouth or tongue while you are being given Cubicin or soon after stopping it, tell your doctor. Also tell your doctor if you get vaginal itching or discharge.
This may mean you have a fungal infection called thrush. Sometimes the use of Cubicin allows fungi to grow and the above symptoms to occur. Cubicin does not work against fungi.
You should tell your doctor that you are being treated with Cubicin if you are about to have a blood clotting test or any other blood tests.
It may interfere with the results of some tests.
If you become pregnant while taking this medicine, tell your doctor immediately.
If you are going to have surgery, tell the surgeon or anaesthetist that you are taking Cubicin.
It may affect other medicines used during surgery.
If you are about to be started on any new medicine, remind your doctor and pharmacist that you are taking Cubicin.
Tell any other doctors, dentists, and pharmacists who treat you that you are taking Cubicin.
Do not stop receiving Cubicin because you are feeling better, unless advised by your doctor.
If you do not complete the full course prescribed by your doctor, all of the bacteria causing your infection may not be killed. These bacteria may continue to grow and multiply so that your infection may not clear completely or it may return.
Do not give this medicine to anyone else, even if their condition seems similar to yours.
Do not use it to treat any other complaints unless your doctor tells you to.
Be careful driving or operating machinery until you know how Cubicin affects you.
Cubicin generally does not cause any problems with your ability to drive a car or operate machinery. However, as with many other medicines, Cubicin may cause dizziness or tiredness in some people.
Tell your doctor or nurse as soon as possible if you do not feel well while you are taking Cubicin.
Cubicin helps most people with infections, but it may have unwanted side-effects in a few people.
All medicines can have side effects. Sometimes they are serious, most of the time they are not. You may need medical treatment if you get some of the side effects.
Do not be alarmed by the following list of side effects. You may not experience any of them.
Ask your doctor or pharmacist to answer any questions you may have.
Tell your doctor or nurse if you notice any of the following and they worry you:
Tell your doctor or nurse immediately if you notice any of the following:
Hypersensitivity reactions (serious allergic reactions including anaphylaxis, angioedema, drug rash with eosinophilia and systemic symptoms (DRESS) and pulmonary eosinophilia); and a serious lung disorder called eosinophilic pneumonia have been reported in patients given Cubicin.
Tell your doctor if you notice anything else that is making you feel unwell.
Some people may have other side effects not yet known or mentioned in this leaflet.
Each Cubicin vial is to be used for one injection or infusion only. Any unused portion remaining in the vial should be discarded.
Tell your doctor immediately if you develop diarrhoea, especially bloody diarrhoea, after your treatment has stopped.
Diarrhoea is a common problem that happens when taking antibiotics. It usually stops when the antibiotic is stopped.
Other medicines of the same class as Cubicin may also cause diarrhoea.
Do not take any diarrhoea medicine without first checking with your doctor.
It is unlikely you will have to store Cubicin powder at home.
If you do have to store it:
Heat and dampness can destroy some medicines.
Keep the medicine where children cannot reach it.
Cubicin is available in a 10 mL glass vial containing a pale yellow to light brown powder.
Each vial contains daptomycin 350 mg or 500 mg as the active ingredient.
It also contains the following inactive ingredient:
Cubicin does not contain preservatives or bacteriostatic agents.