Cubicin infusion contains the active ingredient daptomycin, which is a medicine used to treat infections with bacteria, in particular Staphylococcus aureus bacteria. Daptomycin is a new type of antibiotic known as a lipopeptide antibiotic. It can only be used to treat infections with a specific sub-group of bacteria called Gram positive bacteria.
Daptomycin works by binding to the cell membranes of Gram positive bacteria, causing them to lose potassium. This causes a reaction that rapidly stops the bacteria making proteins and genetic material that they need to survive and multiply. This kills the bacteria and treats the infection.
Daptomycin has a different mechanism of action to all the other classes of antibiotics. This means it can be used to treat Gram positive bacterial infections that are resistant to other antibiotics. An example of this is infection with the "superbug" MRSA (methicillin-resistant staphylococcus aureus). Such bacterial infections have become more common, particularly in hospitals, due to increasing resistance of bacteria to antibiotic treatment. As daptomycin works in a different way to other antibiotics, it may provide doctors with a new line of attack for these types of infections. Other types of antibiotics may be used at the same time as treatment with daptomycin, if necessary.
To make sure the bacteria causing an infection are susceptible to daptomycin your doctor may take a tissue sample, for example a swab from the skin, or a blood sample.
Daptomycin is given by a drip into a vein (intravenous infusion) over 30 minutes.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.
If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.
For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while being treated with this one, to ensure that the combination is safe.
There may be an increased risk of side effects on the muscles (myopathy) if daptomycin is used in combination with any of the following medicines:
The manufacturer recommends that, if possible, the medicines above should be temporarily stopped during treatment with daptomycin. If these medicines cannot be stopped, CPK should be monitored more frequently and patients should be closely monitored for possible signs of side effects on the muscles.
The following medicines can sometimes affect kidney function and so may affect the removal of daptomycin from the body by the kidneys. These medicines should be used with caution in combination with daptomycin:
If you are taking an anticoagulant medicine to prevent blood clots, for example warfarin, your doctor should be aware that daptomycin can sometimes interfere with laboratory tests that measure your blood clotting time (INR or prothrombin time). Daptomycin may suggest that your INR is higher than it actually is. As a result, any adjustments to the dose of your anticoagulant should only be made after taking this into account. If you are having tests to check your blood clotting time it is best that the blood sample is taken just before your daptomycin dose is given, as this is when the level of daptomycin in your blood is at its lowest.
There are currently no other medicines available in the UK that contain daptomycin as the active ingredient.