Curanail (Amorolfine)

How does it work?

Curanail nail lacquer contains the active ingredient amorolfine, which is an antifungal medicine used to treat infections caused by fungi, yeasts and moulds.

Amorolfine kills fungi and yeasts by interfering with their cell membranes. It works by stopping fungi from producing a substance called ergosterol, which is an essential component of fungal cell membranes. The disruption in production of ergosterol disrupts the cell membrane.

The cell membranes of fungi are vital for their survival. They keep unwanted substances from entering the cells and stop the contents of the cells from leaking out. As amorolfine disrupts the cell membranes, it kills the fungal cells.

Curanail nail lacquer is used to treat infections of the nails with fungi (dermatophytes), yeasts and moulds. These types of infections are often difficult to eradicate, because the nails are hard and difficult to penetrate and take a long time to grow as new healthy tissue.

Curanail nail lacquer is painted onto the infected nails like nail varnish. The lacquer is resistant to soap and water and stays on the nails for a week, allowing the medicine to penetrate through the nail into the nail bed and attack the infection.

Before applying the lacquer, the affected areas of nail, including the nail surfaces, should be filed down as thoroughly as possible using one of the disposable nail files supplied. The surface of the nail should then be cleansed using one of the disposable swabs supplied. The nail lacquer should be applied onto to the entire surface of the infected nail(s) using one of the reusable applicators supplied. Allow it to dry for about three minutes. For each nail to be treated, dip the applicator into the nail lacquer without wiping off any of the lacquer on the bottle neck.

After use, it is important clean the applicator before putting it back in the bottle. Use the same swab used earlier for nail cleaning. Dispose of the swab carefully. Keep the bottle tightly closed.

The nail lacquer should be reapplied once a week, as directed by your pharmacist. Each time you reapply the lacquer you should cleanse the nail(s) with a swab to remove any old lacquer first. You should then file the nail(s) down and cleanse them as before, before applying a new coat of the lacquer.

It is important that you continue the treatment without interruption until the infected section of nail has completely grown out, otherwise the infection will just come back. In general it can take six months treatment to clear up a fingernail infection and nine to twelve months for toenail infections. It is recommended that you return to see your pharmacist every three months during the treatment to make sure the medicine is working correctly. If there is no improvement after three months treatment you will need to see your doctor.

If you are treating a toenail infection and you also have athlete's foot, you should ask your pharmacist to recommend a separate medicine (eg cream/spray/powder) so you can treat this at the same time. This will help prevent the toenail getting reinfected. You can also use powders and sprays in your shoes to help keep them free from fungi.

What is it used for?

  • Mild fungal nail infections (onychomycosis caused by dermatophytes, yeasts and moulds) affecting the tips or sides of up to two nails, in adults aged 18 years and over.

Warning!

  • Your pharmacist will need to ask you various questions about your health and other medicines you may be using before they can sell you this medicine. This is to ensure that the medicine is suitable and safe for you to use. If you suffer from diabetes, poor blood circulation in your hands or feet, or an underactive immune system, for example due to disease such as HIV or treatment with medicines such as chemotherapy, immunosuppressants or high-dose corticosteroids, your pharmacist will need to refer you to your doctor to get the nail treated. This also applies if you are pregnant or breastfeeding, for children aged under 18 years and if you have more than two infected nails, a destroyed or very damaged nail, or your pharmacist thinks that your nail condition is not caused by a fungal infection.
  • This medicine is for external use only.
  • Avoid contact with eyes, ears and mucous membranes (eg the inside of the nose and mouth). Do not inhale.
  • The disposable nail files provided with the medicine should be discarded after use. Use a new file for each weekly treatment. Do not use the nail files used for infected nails to file healthy nails, as this may spread the infection.
  • You should not use nail varnish or artificial nails on the nails you are treating with this medicine.
  • If you need to work with organic solvents (eg thinners, white spirit etc) during treatment with this medicine, you should wear waterproof gloves to protect the medicine on the nails.
  • It is important that you continue the treatment without interruption until the infected section of nail has completely grown out, otherwise the infection will just come back. The hardest part may remembering to apply the lacquer each week. It will help to apply the lacquer on the same day each week and write the date of use on a diary card or on the box, to help to keep a running check of when you used to medicine. In general it can take six months treatment to clear up a fingernail infection and nine to twelve months for toenail infections. It is recommended that you return to see your pharmacist every three months during the treatment to make sure the medicine is working correctly. If there is no improvement after three months treatment you will need to see your doctor.

Not to be used in

  • Children under 18 years of age
  • Pregnancy
  • Breastfeeding.

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding

Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

  • The safety of this medicine for use during pregnancy and breastfeeding has not been established. The medicine is unlikely to be absorbed into the body in significant amounts after being applied to the nails, but as there is no experience, the manufacturer states that it should not be used in women who are pregnant or breastfeeding. Seek medical advice from your doctor.

Label warnings

  • Follow the printed instructions you have been given with this medication.

Side effects

Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

  • Burning sensation in area of use

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?

There are no known interactions with this medicine.

Other medicines containing the same active ingredient

Loceryl cream Loceryl nail lacquer