Generic Name: Cyclopentolate/Phenylephrine (sigh-kloe-PEN-toe-late/fen-ill-EFF-rin)Brand Name: Cyclomydril

Cyclomydril is used for:

Dilating (widening) the pupil before an eye exam or eye surgery.

Cyclomydril is an anticholinergic and decongestant combination. It works by relaxing the muscles of the eye, which causes the pupils to widen. It also prevents the eye from focusing on near objects (cycloplegia).

Do NOT use Cyclomydril if:

  • you are allergic to any ingredient in Cyclomydril
  • you have untreated narrow-angle glaucoma

Contact your doctor or health care provider right away if any of these apply to you.

Before using Cyclomydril :

Some medical conditions may interact with Cyclomydril . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you are on high blood pressure therapy
  • if you have numbness due to nerve damage, difficulty urinating due to a bladder neck blockage, heart disease, diabetes, high blood pressure, an overactive thyroid, an increased risk for angle-closure glaucoma, or open-angle glaucoma
  • if you have Down syndrome

Some MEDICINES MAY INTERACT with Cyclomydril . Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Carbachol, cholinesterase inhibitors (eg, demecarium), or pilocarpine used in the eye because their effectiveness may be decreased by Cyclomydril

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cyclomydril may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Cyclomydril :

Use Cyclomydril as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Cyclomydril is for use in the eye only. Avoid contact with other mucous membranes (eg, mouth, nose).
  • To use Cyclomydril , first, wash your hands. Tilt your head back. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Drop the medicine into the pouch and gently close your eyes. Immediately use your finger to apply pressure to the inside corner of the eye for 1 to 2 minutes. Do not blink. Remove excess medicine around your eye with a clean tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them. To prevent germs from contaminating your medicine, do not touch the applicator tip to any surface, including your eye. Keep the container tightly closed.
  • If you are using Cyclomydril in a child's eye, do not get any medicine in the child's mouth. Wash the child's hands and your own after using to remove a ny medicine that may be on them.
  • If you miss a dose of Cyclomydril , contact your doctor immediately.

Ask your health care provider any questions you may have about how to use Cyclomydril .

Important safety information:

  • Do not drive or engage in other hazardous activities while the pupils are dilated.
  • Cyclomydril may cause your eyes to become sensitive to sunlight. Wearing sunglasses may help.
  • Caution is advised when using Cyclomydril in young CHILDREN and INFANTS because they may be more sensitive to its effects, especially behavioral changes, clumsiness, hallucinations, restlessness, and seizures. Feeding intolerance may also occur in infants. It is recommended to delay feeding until 4 hours after the examination or procedure.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Cyclomydril during pregnancy. It is unknown if Cyclomydril is excreted in breast milk. If you are or will be breast-feeding while you are using Cyclomydril , check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Cyclomydril :

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; burning/irritation; decreased saliva and sweat; dry mouth or nose; sensitivity to sunlight.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); changes in behavior; clumsiness; difficulty speaking/walking; difficulty urinating; disorientation; eye inflammation; fast heartbeat; hallucinations; hyperactivity; increased pressure in the eye; psychotic behavior; restlessness; seizures; slurred speech.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (, or emergency room immediately. Symptoms may include blurred vision; change in behavior; difficulty urinating; dry mouth; fast heartbeat; fever.

Proper storage of Cyclomydril :

Store Cyclomydril between 46 and 80 degrees F (8 and 27 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Cyclomydril out of the reach of children and away from pets.

General information:

  • If you have any questions about Cyclomydril , please talk with your doctor, pharmacist, or other health care provider.
  • Cyclomydril is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.

This information is a summary only. It does not contain all information about Cyclomydril . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

  • Cyclomydril Prescribing Information (FDA)
  • Cyclomydril Concise Consumer Information (Cerner Multum)