How does it work?
Ketocid modified release capsules contain the active ingredient ketoprofen, which is a type of medicine called a non-steroidal anti-inflammatory drug (NSAID). NSAIDs are used to relieve pain and inflammation. (NB. Ketoprofen is also available without a brand name, ie as the generic medicine.)
Ketoprofen works by blocking the action of a substance in the body called cyclo-oxygenase (COX). Cyclo-oxygenase is involved in the production of various chemicals in the body, some of which are known as prostaglandins. Prostaglandins are produced by the body in response to injury and certain diseases and conditions, and cause pain, swelling and inflammation. Ketoprofen blocks the production of these prostaglandins and is therefore effective at reducing inflammation and pain.
Ketoprofen is used to relieve pain and inflammation in a wide range of musculoskeletal conditions, including various forms of arthritis, gout, muscle sprains and strains, back pain, neck pain and tendinitis. It can also be used to relieve period pain.
Ketocid modified release capsules are designed to release the ketoprofen slowly and continuously over several hours. This provides prolonged pain relief, so these capsules are taken once a day. The capsules must be swallowed whole to avoid damaging the modified release action.
Ketocid modified release capsules should preferably be taken with food to help avoid irritating the stomach.
What is it used for?
In adults, relief of pain and inflammation in a wide range of conditions, including those listed below.
- Rheumatoid arthritis.
- A form of arthritis affecting the joints of the spine (ankylosing spondylitis).
- Acute gout.
- Acute inflammatory disorders of the joints, such as tendon inflammation (tendinitis), bursitis, capsulitis, synovitis.
- Painful disorders of the muscles and skeleton, such as sprains, strains, fibrositis, dislocations, fractures.
- Neck pain due to inflammation of the vertebrae in the neck (cervical spondylitis).
- Lower back pain.
- Nerve pain that travels from the back into the buttock and back of leg (sciatica).
- Pain and inflammation following orthopaedic (bone) surgery.
- Painful periods (dysmenorrhea).
- Ketocid capsules should be swallowed whole with water and not broken, chewed or crushed. They should be taken with or after food to help avoid irritating the stomach.
- This medicine may cause dizziness and so may affect your ability to drive or operate machinery safely. Do not drive or operate machinery until you know how this medicine affects you and you are sure it won't affect your performance.
- Your doctor will prescribe you the lowest effective dose of this medicine for the shortest possible time necessary to relieve your symptoms. This is to minimise the chances of any side effects, particularly those mentioned below. It is important not to exceed the prescribed dose.
- NSAIDs can occasionally cause serious side effects on the gut, such as ulceration, bleeding or perforation of the stomach or intestinal lining. This type of side effect is more likely to occur in elderly people and in people taking high doses of the medicine. The risk can also be increased by taking certain other medicines (see below). It is important that these people, as well as people with a history of disorders affecting the stomach or intestines, are closely monitored by a doctor while taking this medicine. If your doctor thinks you are at high risk of side effects on the gut you may be prescribed an additional medicine to help protect your gut. All people taking this medicine should stop treatment and consult their doctor immediately if they experience any sign of bleeding from the stomach or intestine during treatment, for example vomiting blood and/or passing black/tarry/bloodstained stools.
- Studies have suggested that use of some NSAIDs may be associated with a small increase in the risk of heart attacks and stroke (particularly if used in high doses or for long periods of time). If you have risk factors for heart disease or stroke, such as diabetes, high blood pressure, high cholesterol or smoking, your doctor will need to assess the overall benefits and risks before deciding if this medicine is suitable for you. Ask your doctor or pharmacist for further information.
- Very rarely, NSAIDS may cause serious blistering or peeling skin reactions (eg Stevens-Johnson syndrome, toxic epidermal necrolysis, exfoliative dermatitis). For this reason, you should stop taking this medicine and consult your doctor if you get a skin rash or sores inside your mouth while taking this medicine. This side effect is very rare, but if it occurs, is most likely to happen in the first month of treatment.
- If you have cirrhosis of the liver, heart failure or kidney disease, or you are taking diuretic medicines, your kidney function should be assessed before starting and regularly throughout treatment with this medicine.
- During long-term treatment with this medicine you should have regular check-ups with your doctor so that you can be monitored for possible side effects of the medicine. This might include routine blood tests to monitor your kidney function, liver function and levels of blood components, particularly if you are elderly.
Use with caution in
- Elderly people.
- History of disorders affecting the stomach or intestines.
- Inflammatory bowel disease such as Crohn's disease or ulcerative colitis.
- Decreased kidney function.
- Decreased liver function.
- Heart failure.
- High blood pressure (hypertension).
- Heart disease caused by inadequate blood flow to the heart (ischaemic heart disease), eg angina or history of heart attack.
- Disease of the blood vessels in and around the brain (cerebrovascular disease), eg history of stroke or mini-stroke (TIA).
- Poor circulation in the arteries of the legs or feet (peripheral arterial disease).
- Raised levels of fats such as cholesterol in the blood (hyperlipidaemia).
- People with blood clotting disorders or taking anticoagulant medicines.
- History of asthma.
- History of allergies.
- Diseases affecting connective tissue, eg systemic lupus erythematosus.
Not to be used in
- People in whom aspirin or other NSAIDs, eg ibuprofen, cause allergic reactions such as asthma attacks, itchy rash (urticaria), nasal inflammation (rhinitis) or swelling of the lips, tongue and throat (angioedema).
- Active peptic ulcer or bleeding from the gut.
- People who have had recurrent peptic ulcers or bleeding from the gut.
- Severely decreased kidney function.
- Severe heart failure.
- This medicine is not recommended for children.
This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.
Pregnancy and breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.
- This medicine is not recommended for use in pregnancy unless considered essential by your doctor. This is particularly important in the first and third trimesters. If taken in the third trimester it may delay labour, increase the length of labour and cause complications in the newborn baby. Some evidence suggests that NSAIDs should also be avoided by women attempting to conceive, as they may temporarily reduce female fertility during treatment and may also increase the risk of miscarriage or malformations. Seek medical advice from your doctor.
- This medicine may pass into breast milk, but in such small quantities that it is unlikely to harm the baby. However, the manufacturer recommends that this medicine is avoided by women who are breastfeeding, unless it is considered essential by your doctor. Seek medical advice from your doctor.
- Take this medication with or after food.
- This medication is to be swallowed whole, not chewed.
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Just because a side effect is stated here does not mean that all people using this medicine will experience that or any side effect.
- Disturbances of the gut, such as indigestion, nausea, vomiting, constipation, diarrhoea, heartburn, abdominal pain.
- Balance disorders involving the inner ear (vertigo).
- Pins and needles sensations.
- Retention of water in the body tissues (fluid retention), resulting in swelling (oedema).
- Mood changes.
- Difficulty sleeping (insomnia).
- Ulceration in the stomach or intestine.
- Bleeding from the stomach or intestine.
- Allergic reactions such as skin rashes, swelling of the lips, tongue and throat (angioedema) or narrowing of the airways (bronchospasm).
- Abnormal reaction of the skin to light, usually a rash (photosensitivity).
- Kidney, liver or blood disorders.
- Visual disturbances.
- Sensation of ringing or other noise in the ears (tinnitus).
The side effects listed above may not include all of the side effects reported by the medicine's manufacturer.For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.
How can this medicine affect other medicines?
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before taking this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while taking this one, to ensure that the combination is safe.
Ketoprofen should not be taken in combination with painkilling doses of aspirin or any other oral NSAID, eg ibuprofen, as this increases the risk of side effects on the stomach and intestines. Selective inhibitors of COX-2 such as celecoxib or etoricoxib should also be avoided for the same reason.
There may be an increased risk of ulceration or bleeding in the gut if ketoprofen is taken with corticosteroids such as prednisolone.
There may also be an increased risk of bleeding in the gut if ketoprofen is taken with the following medicines:
- anti-blood-clotting (anticoagulant) medicines such as warfarin or heparin
- anti-platelet medicines to reduce the risk of blood clots or 'thin the blood', eg low-dose aspirin, clopidogrel, dipyridamole
- SSRI antidepressants, eg fluoxetine, paroxetine, citalopram
Ketoprofen may enhance the effect of blood-thinning or anti-clotting medicines (anticoagulants) such as warfarin. As this may increase the risk of bleeding, people taking ketoprofen with an anticoagulant should be closely monitored by their doctor.
Ketoprofen may reduce the removal of the following medicines from the body and so may increase the blood levels and risk of side effects of these medicines. People taking ketoprofen with any of these should be closely monitored by their doctor:
There may be an increased risk of side effects on the kidneys if ketoprofen is taken with any of the following medicines:
- ACE inhibitors, eg enalapril
- diuretics, eg furosemide
Ketoprofen may oppose the blood pressure lowering effects of certain medicines to treat high blood pressure, such as the following:
- ACE inhibitors such as captopril
- beta-blockers such as propranolol
- diuretics such as furosemide.
Probenecid may increase the blood level of ketoprofen, which may increase the risk of side effects.
Other medicines containing the same active ingredient
|Ketovail ||Orudis ||Oruvail |
|Oruvail gel ||Powergel ||Tiloket |
|Tiloket gel || || |
Ketoprofen capsules, modified release capsules and gel are also available without a brand name, ie as the generic medicine.